Mononuclear Phagocyte Activation Is Associated With the Immunopathology of Psoriasis

Psoriasis is a chronic, inflammatory disease affecting the skin and joints. The pathogenesis of this disease is associated with genetic, environmental and immunological factors, especially unbalanced T cell activation and improper keratinocyte differentiation. Psoriatic lesion infiltrate is composed...

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Bibliographic Details
Published in:Frontiers in immunology 2020-03, Vol.11, p.478-478
Main Authors: Costa, Mariana C, Paixão, Camilla S, Viana, Débora L, Rocha, Bruno de O, Saldanha, Maíra, da Mota, Lícia M H, Machado, Paulo R L, Pagliari, Carla, de Oliveira, Maria de Fátima, Arruda, Sergio, Carvalho, Edgar M, Carvalho, Lucas P
Format: Article
Language:English
Subjects:
Adult
Aged
Aged, 80 and over
Antigens, CD - metabolism
Antigens, Differentiation, Myelomonocytic - metabolism
Cells, Cultured
Chemokine CCL20
Cross-Sectional Studies
cytokines
Humans
Immunology
Leukocytes, Mononuclear - immunology
Lipopolysaccharide Receptors - metabolism
Middle Aged
mononuclear phagocytes
Phagocytes - immunology
psoriasis
Psoriasis - immunology
Receptors, Cell Surface - metabolism
sCD14
sCD163
Skin - metabolism
Skin - pathology
T-Lymphocytes - immunology
Tumor Necrosis Factor-alpha - metabolism
Up-Regulation
Young Adult
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Summary:Psoriasis is a chronic, inflammatory disease affecting the skin and joints. The pathogenesis of this disease is associated with genetic, environmental and immunological factors, especially unbalanced T cell activation and improper keratinocyte differentiation. Psoriatic lesion infiltrate is composed of monocytes and T cells, and most studies have focused on the participation of T cells in the pathogenesis of this disease. Here we investigated the contribution of mononuclear phagocytes in the immunopathology observed in psoriatic patients. Significant increases in the levels of TNF, IL-1β, CXCL9, as well as the soluble forms of CD14 and CD163, were observed within the lesions of psoriatic patients compared to skin biopsies obtained from healthy individuals. Moreover, we found an association between the levels of CCL2, a monocyte attractant chemokine, and disease severity. In conclusion, our findings suggest a potential role for mononuclear phagocytes in the pathogenesis of psoriasis.
ISSN:1664-3224
1664-3224
DOI:10.3389/fimmu.2020.00478