Malignant pheochromocytoma with negative biochemical markers: Is it time to reclassify pheochromocytomas?

Pheochromocytomas are catecholamine producing tumors of adrenal gland generally diagnosed by presence of these markers in urine or plasma. However, a few may be marker-negative and challenging for clinicians. Several reports of these marker-negative pheochromocytomas may warrant necessity for a new...

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Bibliographic Details
Published in:Urology case reports 2019-05, Vol.24, p.100858, Article 100858
Main Authors: Borzouei, Shiva, Mousavi-bahar, Seyed Habibollah, Salimbahrami, Sayed Ahmadreza, Sardari Masihi, Mher
Format: Article
Language:English
Subjects:
Adrenal
Catecholamines
Hypertension
Pheochromocytoma
Trauma and Reconstruction
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Summary:Pheochromocytomas are catecholamine producing tumors of adrenal gland generally diagnosed by presence of these markers in urine or plasma. However, a few may be marker-negative and challenging for clinicians. Several reports of these marker-negative pheochromocytomas may warrant necessity for a new classification of these tumors. Adrenergic blockade before surgery is one of the main reasons for recognition of these cases. We present a case of marker-negative pheochromocytoma which turned out to be malignant on its recurrence. To our knowledge, this is the only case of malignant marker-negative pheochromocytoma reported in literature so far.
ISSN:2214-4420
2214-4420
DOI:10.1016/j.eucr.2019.100858