The Interplay between Obesity and Inflammation

Obesity is an important condition affecting the quality of life of numerous patients and increasing their associated risk for multiple diseases, including tumors and immune-mediated disorders. Inflammation appears to play a major role in the development of obesity and represents a central point for...

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Published in:Life (Basel, Switzerland) Switzerland), 2024-07, Vol.14 (7), p.856
Main Authors: Savulescu-Fiedler, Ilinca, Mihalcea, Razvan, Dragosloveanu, Serban, Scheau, Cristian, Baz, Radu Octavian, Caruntu, Ana, Scheau, Andreea-Elena, Caruntu, Constantin, Benea, Serban Nicolae
Format: Article
Language:English
Subjects:
Adipocytes
adipokines
Adipose tissue
Apoptosis
Body fat
Comorbidity
Cytokines
Energy
Fatty acids
Health risks
Immune system
Inflammation
Lipids
Lymphocytes
Macrophages
Metabolic disorders
Neutrophils
Obesity
Phenotypes
Quality of life
Thermogenesis
Tumor necrosis factor-TNF
Weight control
Weight loss
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Summary:Obesity is an important condition affecting the quality of life of numerous patients and increasing their associated risk for multiple diseases, including tumors and immune-mediated disorders. Inflammation appears to play a major role in the development of obesity and represents a central point for the activity of cellular and humoral components in the adipose tissue. Macrophages play a key role as the main cellular component of the adipose tissue regulating the chronic inflammation and modulating the secretion and differentiation of various pro- and anti-inflammatory cytokines. Inflammation also involves a series of signaling pathways that might represent the focus for new therapies and interventions. Weight loss is essential in decreasing cardiometabolic risks and the degree of associated inflammation; however, the latter can persist for long after the excess weight is lost, and can involve changes in macrophage phenotypes that can ensure the metabolic adjustment. A clear understanding of the pathophysiological processes in the adipose tissue and the interplay between obesity and chronic inflammation can lead to a better understanding of the development of comorbidities and may ensure future targets for the treatment of obesity.
ISSN:2075-1729
2075-1729
DOI:10.3390/life14070856