Global analysis of cytochrome c oxidase subunit 1 (cox1) gene variation in Dibothriocephalus nihonkaiensis (Cestoda: Diphyllobothriidae)

The cestode Dibothriocephalus nihonkaiensis (syns. Diphyllobothrium nihonkaiense and Diphyllobothrium klebanovskii), the broad fish tapeworm, is a parasitic agent of intestinal infection acquired by consumption of raw or undercooked Pacific salmon, Onchorhynchus spp. Sequencing studies conducted abo...

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Published in:Current research in parasitology & vector-borne diseases 2021-01, Vol.1, p.100042-100042, Article 100042
Main Authors: Abe, Niichiro, Baba, Takashi, Nakamura, Yoshitaka, Murakami, Shintaro
Format: Article
Language:English
Subjects:
Dibothriocephalus nihonkaiensis
Diphyllobothriidae
Genetic diversity
Haplotype network
Humans
Japan
Pacific salmon
Short Communication
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Summary:The cestode Dibothriocephalus nihonkaiensis (syns. Diphyllobothrium nihonkaiense and Diphyllobothrium klebanovskii), the broad fish tapeworm, is a parasitic agent of intestinal infection acquired by consumption of raw or undercooked Pacific salmon, Onchorhynchus spp. Sequencing studies conducted about a decade ago revealed the presence of two major lineages (A and B) in the broad fish tapeworm population within Asian coastal areas. However, in spite of the accumulation of sequence data on GenBank recently, no further genetic analyses of D. nihonkaiensis have been attempted. The present study assessed for the first time the global cox1 variation in D. nihonkaiensis. Novel partial cox1 sequences of 14 isolates of D. nihonkaiensis from 12 patients were generated, and a global genetic analysis was performed using the 14 novel and 79 previously published sequences for isolates from definitive and second intermediate hosts of this species was performed. A total of 48 haplotypes of three haplotype groups (Types A, B and C) were identified, and co-infections with genetically different D. nihonkaiensis were highlighted in humans and Pacific salmon. [Display omitted] •First global analysis of cox1 variation in Dibothriocephalus nihonkaiensis.•First application of haplotype network analysis for a D. nihonkaiensis population.•A total of 48 haplotypes of three haplotype groups (Type A, B and C) are identified.•Co-infections with heterogenic isolates in definitive and intermediate hosts are highlighted.
ISSN:2667-114X
2667-114X
DOI:10.1016/j.crpvbd.2021.100042