A novel long non-coding RNA, AC012456.4, as a valuable and independent prognostic biomarker of survival in oral squamous cell carcinoma

Oral squamous cell carcinoma (OSCC) is a major malignant cancer of the head and neck. Long non-coding RNAs (lncRNAs) have emerged as critical regulators during the development and progression of cancers. This study aimed to identify a lncRNA-related signature with prognostic value for evaluating sur...

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Bibliographic Details
Published in:PeerJ (San Francisco, CA) CA), 2018-08, Vol.6, p.e5307-e5307, Article e5307
Main Authors: Hu, Xuegang, Qiu, Zailing, Zeng, Jianchai, Xiao, Tingting, Ke, Zhihong, Lyu, Hongbing
Format: Article
Language:English
Subjects:
AC012456.4
Bioinformatics
Computational Science
Long non-coding RNAs (lncRNAs)
Oncology
Oral squamous cell carcinoma (OSCC)
Prognostic biomarkers
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Summary:Oral squamous cell carcinoma (OSCC) is a major malignant cancer of the head and neck. Long non-coding RNAs (lncRNAs) have emerged as critical regulators during the development and progression of cancers. This study aimed to identify a lncRNA-related signature with prognostic value for evaluating survival outcomes and to explore the underlying molecular mechanisms of OSCC. Associations between overall survival (OS), disease-free survival (DFS) and candidate lncRNAs were evaluated by Kaplan-Meier survival analysis and univariate and multivariate Cox proportional hazards regression analyses. The robustness of the prognostic significance was shown via the Gene Expression Omnibus (GEO) database. A total of 2,493 lncRNAs were differentially expressed between OSCC and control samples (fold change >2,  
ISSN:2167-8359
2167-8359
DOI:10.7717/peerj.5307