Benzothiazole Derivatives as Multifunctional Antioxidant Agents for Skin Damage: Structure-Activity Relationship of a Scaffold Bearing a Five-Membered Ring System

Skin diseases often give multifactorial damages; therefore, the development of multifunctional compounds represents a suitable approach especially against disorders that are induced by oxidative stress. Thus, taking into account the successful results we achieved on benzimidazoles, we have devised a...

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Bibliographic Details
Published in:Antioxidants 2022-02, Vol.11 (2), p.407
Main Authors: Djuidje, Ernestine Nicaise, Barbari, Riccardo, Baldisserotto, Anna, Durini, Elisa, Sciabica, Sabrina, Balzarini, Jan, Liekens, Sandra, Vertuani, Silvia, Manfredini, Stefano
Format: Article
Language:English
Subjects:
Alzheimer's disease
antimicrobial
Antimicrobial agents
antioxidant
Antioxidants
Arthritis
Atherosclerosis
Benzimidazoles
Benzothiazole
Cancer
Chemistry
cosmeceutical
Drugs
Free radicals
Inflammation
Melanoma
multifunctional
Oxidative stress
Skin diseases
Tumor cells
UV filter
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Summary:Skin diseases often give multifactorial damages; therefore, the development of multifunctional compounds represents a suitable approach especially against disorders that are induced by oxidative stress. Thus, taking into account the successful results we achieved on benzimidazoles, we have devised a new series of isosteric benzothiazoles and investigated their antioxidant, photoprotective, antifungal and antiproliferative activity. Particular attention has been paid to synergistic antioxidant and photoprotective properties. For compounds and , a multifunctional profile was outlined, supported by an excellent filtering capacity, mainly UVB, which has higher capacities than those of the reference PBSA which is currently in the market as a UV sunscreen filter. The two compounds were also the best in terms of growth inhibition of dermatophytes and Candida albicans, and also showed good antioxidant activity. Furthermore, was also effective on melanoma tumor cells (SK-Mel 5), making these compounds good candidates in the development of new skin protective and preventive agents.
ISSN:2076-3921
2076-3921
DOI:10.3390/antiox11020407