Exploring the Bioactive Potentials of C60-AgNPs Nano-Composites against Malignancies and Microbial Infections

• Published in: International journal of molecular sciences 2022-01, Vol.23 (2), p.714
• Main Authors: Biswas, Kunal, Mishra, Awdhesh Kumar, Rauta, Pradipta Ranjan, Al-Sehemi, Abdullah G., Pannipara, Mehboobali, Sett, Avik, Bratovcic, Amra, Avula, Satya Kumar, Mohanta, Tapan Kumar, Saravanan, Muthupandian, Mohanta, Yugal Kishore
• Format: Article
• Language: English
• Subjects: Adenocarcinoma; AgNPs; Antibiotics; Antiinfectives and antibacterials; Antimicrobial activity; Antimicrobial agents; antimicrobials; antioxidants; Biocompatibility; Breast; breast adenocarcinoma; Breast cancer; Buckminsterfullerene; Carbon; Drug delivery; Drug development; fullerene; Fullerenes; in-vitro; Laboratories; Magnetic moments; Microorganisms; Morphology; Nanocomposites; Nanoparticles; NMR; Nuclear magnetic resonance; Oxygen atoms; Physicochemical properties; Scanning electron microscopy; Silver; Solvents; Tumor cell lines
• ISSN: 1422-0067; 1661-6596; 1422-0067
• DOI: 10.3390/ijms23020714

At present, the potential role of the AgNPs/endo-fullerene molecule metal nano-composite has been evaluated over the biosystems in-vitro. The intra-atomic configuration of the fullerene molecule (C60) has been studied in-vitro for the anti-proliferative activity of human breast adenocarcinoma (MDA-MB-231) cell lines and antimicrobial activity against a few human pathogens that have been augmented with the pristine surface plasmonic electrons and antibiotic activity of AgNPs. Furthermore, FTIR revealed the basic vibrational signatures at ~3300 cm−1, 1023 cm−1, 1400 cm−1 for O-H, C-O, and C-H groups, respectively, for the carbon and oxygen atoms of the C60 molecule. NMR studies exhibited the different footprints and magnetic moments at ~7.285 ppm, explaining the unique underlying electrochemical attributes of the fullerene molecule. Such unique electronic and physico-chemical properties of the caged carbon structure raise hope for applications into the drug delivery domain. The in-vitro dose-dependent application of C60 elicits a toxic response against both the breast adenocarcinoma cell lines and pathogenic microbes. That enables the use of AgNPs decorated C60 endo fullerene molecules to design an effective anti-cancerous drug delivery and antimicrobial agent in the future, bringing a revolutionary change in the perspective of a treatment regime.