Up-regulated serum lactate dehydrogenase could become a poor prognostic marker in patients with bladder cancer by an evidence-based analysis of 2,182 patients

BackgroundA growing number of studies have considered serum lactate dehydrogenase (LDH) as an indicator of bladder cancer (BC) prognosis. However, a meta-analysis of the serum LDH's influence on BC prognosis is still missing. MethodsPubMed, EMBASE, Web of Science and Cochrane Library were exhau...

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Published in:Frontiers in oncology 2023-08, Vol.13, p.1233620-1233620
Main Authors: Wei, Xiaoyu, Chai, Yumeng, Li, Zhouyue, Che, Xuanyan, Zhang, Yong, Zhou, Zhongbao, Wang, Xiang
Format: Article
Language:English
Subjects:
bladder cancer
evidence-based analysis
lactate dehydrogenase
Oncology
overall survival
prognosis
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Summary:BackgroundA growing number of studies have considered serum lactate dehydrogenase (LDH) as an indicator of bladder cancer (BC) prognosis. However, a meta-analysis of the serum LDH's influence on BC prognosis is still missing. MethodsPubMed, EMBASE, Web of Science and Cochrane Library were exhaustively searched for studies comparing oncological outcomes between high-LDH and low-LDH patients. Standard cumulative analyses using hazard ratios (HR) with 95% confidence intervals (CI) were performed using Review Manager (version 5.3) for overall survival (OS) in patients with BC. ResultsSix studies involving 2,182 patients were selected according to predefined eligibility criteria. The results showed that serum LDH level was significantly associated with OS (HR = 1.86, 95%CI = 1.54-2.25, p1 and p
ISSN:2234-943X
2234-943X
DOI:10.3389/fonc.2023.1233620