Value of Albumin-Fibrinogen Ratio and CRP-Albumin Ratio as Predictor Marker of Disease Activity in Egyptian RA Patients, Correlated with Musculoskeletal Sonography

To evaluate the albumin-fibrinogen ratio (AFR) and C-reactive protein-albumin ratio (CAR) as inflammatory markers in rheumatoid arthritis (RA) and to investigate their association with disease activity correlating with musculoskeletal ultrasonographic findings. A total of 125 cases of RA patients we...

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Bibliographic Details
Published in:Open access rheumatology: research and reviews 2020-01, Vol.12, p.241-248
Main Authors: Afifi, Naglaa, M Medhat, Basma, Abdel Ghani, Amani Mohamed, Mohamed Ali Hassan, Hend Galal Eldeen, Behiry, Mervat E
Format: Article
Language:English
Subjects:
albumin- fibrinogen ratio
Biomarkers
c-reactive protein
Disease
Inflammation
Laboratories
Original Research
Patients
Proteins
Rheumatoid arthritis
Rheumatology
Ultrasonic imaging
ultrasonography
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Summary:To evaluate the albumin-fibrinogen ratio (AFR) and C-reactive protein-albumin ratio (CAR) as inflammatory markers in rheumatoid arthritis (RA) and to investigate their association with disease activity correlating with musculoskeletal ultrasonographic findings. A total of 125 cases of RA patients were consecutively enrolled in a multicenter cross-sectional study compared to 100 healthy controls, all subjects were investigated for fibrinogen, albumin, CRP, erythrocyte sedimentation rate, AFR, and CAR measurements. Patients' disease activity was assessed by disease activity score (DAS28-ESR), and they were subjected to high-frequency ultrasound both in greyscale and power Doppler. RA patients had lower AFR and higher CAR than those in the control group (P < 0.001). A positive correlation was demonstrated between CAR and DAS score (r=0.589, P = 0.0001), whilst there was a precise negative correlation between AFR and DAS 28-ESR (r=-0.74, p
ISSN:1179-156X
1179-156X
DOI:10.2147/OARRR.S268668