Nucleus accumbens circuit disinhibits lateral hypothalamus glutamatergic neurons contributing to morphine withdrawal memory in male mice

The lateral hypothalamus (LH) is physiologically critical in brain functions. The LH also plays an important role in drug addiction. However, neural circuits underlying LH involvement of drug addiction remain obscure. In the present study,our results showed that in male mice, during context-induced...

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Published in:Nature communications 2023-01, Vol.14 (1), p.71-16, Article 71
Main Authors: Sheng, Huan, Lei, Chao, Yuan, Yu, Fu, Yali, Cui, Dongyang, Yang, Li, Shao, Da, Cao, Zixuan, Yang, Hao, Guo, Xinli, Chu, Chenshan, Wen, Yaxian, Cai, Zhangyin, Chen, Ming, Lai, Bin, Zheng, Ping
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Subjects:
13/51
14/32
38/77
631/378/1595
631/378/1595/1395
631/378/3920
64/110
64/60
9/74
96/1
96/63
Addictions
Animals
Circuits
Context
Dopamine
Dopamine D1 receptors
Drug addiction
Drug withdrawal
Glutamatergic transmission
Humanities and Social Sciences
Hypothalamic Area, Lateral - metabolism
Hypothalamus
Hypothalamus (lateral)
Luteinizing hormone
Male
Males
Mice
Morphine
Morphine - adverse effects
multidisciplinary
Neural networks
Neurons
Neurons - metabolism
Nucleus accumbens
Nucleus Accumbens - metabolism
Receptors, Dopamine D1 - metabolism
Science
Science (multidisciplinary)
Spiny neurons
Substance-Related Disorders - metabolism
Withdrawal
γ-Aminobutyric acid
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container_title Nature communications
container_volume 14
creator Sheng, Huan
Lei, Chao
Yuan, Yu
Fu, Yali
Cui, Dongyang
Yang, Li
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Yang, Hao
Guo, Xinli
Chu, Chenshan
Wen, Yaxian
Cai, Zhangyin
Chen, Ming
Lai, Bin
Zheng, Ping
description The lateral hypothalamus (LH) is physiologically critical in brain functions. The LH also plays an important role in drug addiction. However, neural circuits underlying LH involvement of drug addiction remain obscure. In the present study,our results showed that in male mice, during context-induced expression of morphine withdrawal memory, LH glutamatergic neurons played an important role; dopamine D1 receptor-expressing medium spiny neurons (D1-MSNs) projecting from the core of nucleus accumbens (NAcC) to the LH were an important upstream circuit to activate LH glutamatergic neurons; D1-MSNs projecting from the NAcC to the LH activated LH glutamatergic neurons through inhibiting LH local gamma-aminobutyric acid (GABA) neurons. These results suggest that disinhibited LH glutamatergic neurons by neural circuits from the NAcC importantly contribute to context-induced the expression of morphine withdrawal memory. Lateral hypothalamus (LH) plays an role in drug addiction. Here, authors present evidence for disinhibited LH glutamatergic neurons by neural circuits from nucleus accumbens to contribute to context-induced expression of morphine withdrawal memory.
doi_str_mv 10.1038/s41467-022-35758-5
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subjects 13/51
14/32
38/77
631/378/1595
631/378/1595/1395
631/378/3920
64/110
64/60
9/74
96/1
96/63
Addictions
Animals
Circuits
Context
Dopamine
Dopamine D1 receptors
Drug addiction
Drug withdrawal
Glutamatergic transmission
Humanities and Social Sciences
Hypothalamic Area, Lateral - metabolism
Hypothalamus
Hypothalamus (lateral)
Luteinizing hormone
Male
Males
Mice
Morphine
Morphine - adverse effects
multidisciplinary
Neural networks
Neurons
Neurons - metabolism
Nucleus accumbens
Nucleus Accumbens - metabolism
Receptors, Dopamine D1 - metabolism
Science
Science (multidisciplinary)
Spiny neurons
Substance-Related Disorders - metabolism
Withdrawal
γ-Aminobutyric acid
title Nucleus accumbens circuit disinhibits lateral hypothalamus glutamatergic neurons contributing to morphine withdrawal memory in male mice
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