The influence of the extraction method on polyphenols, flavonoids composition and anti-hyperlipidemic properties of papaya leaves (Carica papaya Linn.)

Background Papaya ( Carica papaya Linn.) is well known for its nutritional as well as medicinal value. Different parts of the plant including leaves have been used as therapeutic remedies for various diseases. The objective of the present study is to determine the impact of different extraction meth...

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Bibliographic Details
Published in:Bulletin of the National Research Centre 2021-05, Vol.45 (1), p.1-9, Article 85
Main Authors: Abdel-Halim, Sally, Ibrahim, Magda, Abdel Mohsen, Mona, Abou-Setta, Lobna, Sleem, Amany, El-Missiry, Mostafa
Format: Article
Language:English
Subjects:
Anti-hyperlipidemic
Carica papaya
Carica papaya leaves
Composition
Ethanol
Flavonoids
Food Industries
High-performance liquid chromatography
Humanities and Social Sciences
Hypolipidemic activity
Innovative extraction methods
Leaves
Lipids
Liquid chromatography
Maceration
Medicinal plants
multidisciplinary
Papayas
Phenolic compounds
Phenols
Polyphenols
Science
Science (multidisciplinary)
Simvastatin
Ultrasonic testing
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Summary:Background Papaya ( Carica papaya Linn.) is well known for its nutritional as well as medicinal value. Different parts of the plant including leaves have been used as therapeutic remedies for various diseases. The objective of the present study is to determine the impact of different extraction methods; microwave-assisted, ultrasonic-assisted and conventional maceration on extract yield, polyphenols, flavonoids composition and subsequently, the anti-hyperlipidemic potential of papaya leaves ( Carica papaya Linn.). Results Innovative extraction methods represented in microwave assisted extraction (MAE) and ultrasonic assisted extraction (UAE) have significant impact on the extract yield and total phenolic and flavonoids content than conventional maceration extraction (CME) of the prepared aqueous ethanol extracts. HPLC assay showed the highest content of bioactive polyphenols characterized extract from the MAE (29.99 mg/g), followed by UAE (24.75 mg/g) and the lowest content was that obtained from CME. The aqueous ethanol extract of the leaves obtained by MAE induced significant hypolipidemic activity ( P  
ISSN:2522-8307
2522-8307
DOI:10.1186/s42269-021-00548-4