Impact of liver fibrosis score on prognosis after common therapies for intrahepatic cholangiocarcinoma: a propensity score matching analysis

Liver fibrosis or cirrhosis is associated with the dismal prognosis of hepatocellular carcinoma (HCC), and it might also be involved in intrahepatic cholangiocarcinoma (ICC). The effect of hepatic fibrosis on the survival of ICC patients is still unclear. This study aims to explore whether liver fib...

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Bibliographic Details
Published in:BMC cancer 2020-06, Vol.20 (1), p.556-556, Article 556
Main Authors: Zhang, Jian Xi, Li, Peipei, Chen, Zhibin, Lin, Huogui, Cai, Zhezhen, Liao, Weijia, Pan, Zirong
Format: Article
Language:English
Subjects:
Aged
Analysis
Bile Duct Neoplasms - complications
Bile Duct Neoplasms - mortality
Bile Duct Neoplasms - pathology
Bile Duct Neoplasms - therapy
Bile Ducts, Intrahepatic - pathology
Biliary tract cancer
Cancer therapies
Chemotherapy
Cholangiocarcinoma
Cholangiocarcinoma - complications
Cholangiocarcinoma - mortality
Cholangiocarcinoma - pathology
Cholangiocarcinoma - therapy
Cirrhosis
Epidemiology
Female
Fibrosis
Follow-Up Studies
Hepatocellular carcinoma
Humans
Intrahepatic cholangiocarcinoma
Kaplan-Meier Estimate
Liver
Liver cancer
Liver cirrhosis
Liver Cirrhosis - diagnosis
Liver Cirrhosis - etiology
Liver Cirrhosis - pathology
Liver fibrosis
Male
Medical prognosis
Medical research
Metastasis
Middle Aged
Patients
Population
Prognosis
Propensity Score
Regression analysis
Risk Factors
SEER Program - statistics & numerical data
Severity of Illness Index
Statistical analysis
Surgery
Survival
Survival analysis
Treatment Outcome
Tumors
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Summary:Liver fibrosis or cirrhosis is associated with the dismal prognosis of hepatocellular carcinoma (HCC), and it might also be involved in intrahepatic cholangiocarcinoma (ICC). The effect of hepatic fibrosis on the survival of ICC patients is still unclear. This study aims to explore whether liver fibrosis impacts the overall survival (OS) and disease-specific survival (DSS) of ICC patients. Data of 729 eligible ICC patients receiving different therapies from the Surveillance, Epidemiology, and End Results database (2004-2015) were analyzed. Unmatched, propensity score-matched, and propensity score-weighted cohorts were used to investigate the relationships of different fibrosis scores (low fibrosis score vs. high fibrosis score) and survival. A Cox regression and Kaplan-Meier curves were used to explore the influence of fibrosis score on patients' survival. Stratified analyses based on treatment modality were conducted to compare the survival difference in ICC patients with different fibrosis scores. Before matching, the one-, three-, and five-year OS were 50.9, 28.0, and 16.1% in the low fibrosis score group (n = 465) and 39.3, 20.1, and 8.0% in the high fibrosis score group (n = 264) (P 
ISSN:1471-2407
1471-2407
DOI:10.1186/s12885-020-07051-5