Can magnesium sulfate prophylaxis reduce colistin nephrotoxicity?

• Published in: Nefrología 2021-11, Vol.41 (6), p.661-669
• Main Authors: Yasemin Coşkun Yavuz, Nihal Cetin, Esma Menevşe, Ahmet Cizmecioglu, Esin Celik, Zeynep Biyik, Can Sevinc, Serkan Yavuz, Muslu Kazim Korez, Lutfullah Altintepe
• Format: Article
• Language: Spanish
• Subjects: Colistina; Estrés oxidativo; Magnesio; Modelo de rata; Nefrotoxicidad
• ISSN: 0211-6995

The study aimed to investigate the role of magnesium sulfate prophylaxis in nephrotoxicity caused by colistin. Thirty Wistar Albino rats were divided into four groups: control, colistin, magnesium (Mg), and Mg + colistin. The drugs were administered to the groups for seven days. Urea-creatinine values were measured at the beginning (T0) and end (T1) of the study. Malondialdehyde (MDA) levels were measured in plasma and kidney tissue, glutathione (GSH) levels were analyzed in the erythrocyte and kidney tissues. At the end of the study, the semiquantitative score (SQS) was calculated by the histopathological examination of the kidneys. Urea values significantly decreased in Mg and Mg + colistin groups compared to the baseline (p = 0.013 and p = 0.001). At the time of T1, these groups had significantly lower urea values than the colistin and control groups. Creatinine value was significantly increased in the colistin group compared to baseline (p = 0.005), the creatinine value in the colistin group was significantly higher than the Mg + colistin group (p = 0.011). Plasma MDA levels were significantly higher in the colistin group compared to the other groups at the time of T1 (p