Associations Between Thyroid Hormones Levels and Gray Matter Volume of Frontal Lobe Involved into Violence in Male Schizophrenia Patients

Thyroid dysfunction and frontal lobe gray matter volume (GMV) alterations are associated with violence in schizophrenia (SCZ); however, little is known about the relationship between thyroid dysfunction and frontal lobe GMV. This study aimed to evaluate whether thyroid hormone levels were associated...

Full description

Saved in:
Bibliographic Details
Published in:Neuropsychiatric disease and treatment 2024-01, Vol.20, p.2169-2175
Main Authors: Yu, Tao, Pei, Wenzhi, Zhang, Xulai, Deng, Chenchen
Format: Article
Language:English
Subjects:
Aggression
Aggressiveness
Frontal lobe
gray matter volume
Hormones
Magnetic resonance imaging
Mental disorders
mri
Psychotropic drugs
Schizophrenia
structures
Substantia grisea
thyroid
Thyroid diseases
Thyroid hormones
Thyroid-stimulating hormone
Thyroxine
Triiodothyronine
Violence
Citations: Items that this one cites
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Thyroid dysfunction and frontal lobe gray matter volume (GMV) alterations are associated with violence in schizophrenia (SCZ); however, little is known about the relationship between thyroid dysfunction and frontal lobe GMV. This study aimed to evaluate whether thyroid hormone levels were associated with frontal lobe GMV in male patients with schizophrenia and violence. Fifty-five male patients with SCZ underwent triiodothyronine (T3), thyroxine (T4), thyroid-stimulating hormone (TSH), free triiodothyronine (fT3), and free thyroxine (fT4) tests and structural magnetic resonance imaging (sMRI) scans. The sMRI data were processed using the FreeSurfer version 5.0. Multiple linear stepwise regression analysis was used to investigate the relationship between frontal lobe GMV and thyroid hormone levels in all patients. Patients with SCZ and violence exhibited lower GMV of the left frontal pole and higher TSH levels than those without violence. After controlling for potential covariates, the frontal pole GMV was negatively associated with TSH levels in all participants. These findings expand our understanding of the influence of TSH on frontal pole GMV in patients with schizophrenia and violence.
ISSN:1176-6328
1178-2021
1178-2021
DOI:10.2147/NDT.S481875