Effects of tadalafil to prevent injury on corpus cavernosum after vascular or nervous peri-prostatic bundle injury. Experimental model in rats

Abstract Purpose: To evaluate the effects of tadalafil (TD) in preventing histological alterations of the corpus cavernosum caused by isolated lesions of cavernous nerve (ILCN) and artery (ILCA) in rats. Methods: Fifty male Wistar rats were randomly assigned in five groups: G1: control; G2: bilatera...

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Published in:Acta cirúrgica brasileira 2019-01, Vol.34 (9)
Main Authors: Toledo, Antônio Carlos de, Kawano, Paulo Roberto, Yamamoto, Hamilto Akihissa, Guerra, Rodrigo, Gomes Filho, Fernando Ferreira, Pajolli, Pedro Ivo Rochetti, Amaro, João Luiz, Cardoso, Luiz Eduardo Macedo, Sampaio, Francisco José
Format: Article
Language:English
Subjects:
Collagen
Elastin
Erectile Dysfunction
Rats
Tadalafil
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Summary:Abstract Purpose: To evaluate the effects of tadalafil (TD) in preventing histological alterations of the corpus cavernosum caused by isolated lesions of cavernous nerve (ILCN) and artery (ILCA) in rats. Methods: Fifty male Wistar rats were randomly assigned in five groups: G1: control; G2: bilateral ILCN; G3: bilateral ILCA; G4: ILCN+TD; G5: ILCA+TD. The cavernous bodies were submitted to histomorphometry, immunohistochemistry and biochemical analysis. Results: Nerve density was significantly higher in G2 and G4 compared to control (22.62±2.84 and 19.53±3.47 vs. 15.72±1.82; respectively, p
ISSN:0102-8650
1678-2674
DOI:10.1590/s0102-865020190090000001