Circadian Clocks and the Interaction between Stress Axis and Adipose Function

Many physiological processes and most endocrine functions show fluctuations over the course of the day. These so-called circadian rhythms are governed by an endogenous network of cellular clocks and serve as an adaptation to daily and, thus, predictable changes in the organism’s environment. Circadi...

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Bibliographic Details
Published in:International Journal of Endocrinology 2015-01, Vol.2015 (2015), p.563-575-171
Main Authors: Kolbe, Isa, Oster, Henrik, Dumbell, Rebecca
Format: Article
Language:English
Subjects:
Adipose tissues
Adrenal glands
Circadian rhythm
Circadian rhythms
Endocrinology
Feedback
Hypothalamus
Metabolic disorders
Physiological aspects
Physiology
Psychological aspects
Review
Risk factors
Sleep
Stress (Psychology)
Transcription factors
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Summary:Many physiological processes and most endocrine functions show fluctuations over the course of the day. These so-called circadian rhythms are governed by an endogenous network of cellular clocks and serve as an adaptation to daily and, thus, predictable changes in the organism’s environment. Circadian clocks have been described in several tissues of the stress axis and in adipose cells where they regulate the rhythmic and stimulated release of stress hormones, such as glucocorticoids, and various adipokine factors. Recent work suggests that both adipose and stress axis clock systems reciprocally influence each other and adrenal-adipose rhythms may be key players in the development and therapy of metabolic disorders. In this review, we summarize our current understanding of adrenal and adipose tissue rhythms and clocks and how they might interact to regulate energy homoeostasis and stress responses under physiological conditions. Potential chronotherapeutic strategies for the treatment of metabolic and stress disorders are discussed.
ISSN:1687-8337
1687-8345
DOI:10.1155/2015/693204