Establishing Salvia miltiorrhiza -Derived Exosome-like Nanoparticles and Elucidating Their Role in Angiogenesis

• Published in: Molecules (Basel, Switzerland) Switzerland), 2024-04, Vol.29 (7), p.1599
• Main Authors: Zhang, Shuya, Xia, Jiaxuan, Zhu, Ying, Dong, Meichen, Wang, Jianxin
• Format: Article
• Language: English
• Subjects: Angiogenesis; angiogenesis promoters; Animals; Blood vessels; Cardiac function; Cell culture; Cell growth; Centrifuges; Danshen-derived exosome-like nanoparticles; Exosomes; Heart attacks; Human Umbilical Vein Endothelial Cells; Humans; Ischemia; Mammals; Microscopy; myocardial ischemia–reperfusion injury; Myocardial Reperfusion Injury - drug therapy; Nanoparticles; Oxidative stress; Particle size; Physiology; Salvia miltiorrhiza; Stem cells; Sucrose; Transcription Factors
• ISSN: 1420-3049; 1420-3049
• DOI: 10.3390/molecules29071599

Exosomes are multifunctional, cell-derived nanoscale membrane vesicles. Exosomes derived from certain mammalian cells have been developed as angiogenesis promoters for the treatment of myocardial ischemia-reperfusion injury, as they possess the capability to enhance endothelial cell proliferation, migration, and angiogenesis. However, the low yield of exosomes derived from mammalian cells limits their clinical applications. Therefore, we chose to extract exosome-like nanoparticles from the traditional Chinese medicine , which has been shown to promote angiogenesis. -derived exosome-like nanoparticles offer advantages, such as being economical, easily obtainable, and high-yielding, and have an ideal particle size, Zeta potential, exosome-like morphology, and stability. -derived exosome-like nanoparticles can enhance the cell viability of Human Umbilical Vein Endothelial Cells and can promote cell migration and improve the neovascularization of the cardiac tissues of myocardial ischemia-reperfusion injury, indicating their potential as angiogenesis promoters for the treatment of myocardial ischemia-reperfusion injury.