Effectiveness of etofenamate for treatment of knee osteoarthritis: a randomized controlled trial

The intramuscular application of etofenamate in the treatment of knee osteoarthritis was not observed in the existing English language literature. The objectives of this study were to compare the efficacy of etofenamate versus hyaluronic acid (HA) in reducing joint pain and functional improvement fo...

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Bibliographic Details
Published in:Therapeutics and clinical risk management 2016-01, Vol.12, p.1693-1699
Main Authors: Guner, Sukriye Llkay, Unsal, Seyyid Serif, Gozen, Abdurrahim, Gokalp, Mehmet Ata, Guner, Savas
Format: Article
Language:English
Subjects:
Analysis
Arthralgia
Arthritis
Colleges & universities
Comparative analysis
Dosage and administration
Drug therapy
Etofenamate
Evidence-based medicine
Health aspects
Hyaluronic acid
Knee
Knee Osteoarthritis
Nonsteroidal anti-inflammatory drugs
Original Research
Osteoarthritis
Treatment
Treatment outcome
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Summary:The intramuscular application of etofenamate in the treatment of knee osteoarthritis was not observed in the existing English language literature. The objectives of this study were to compare the efficacy of etofenamate versus hyaluronic acid (HA) in reducing joint pain and functional improvement for mild to moderate knee osteoarthritis. The patients were randomly divided into etofenamate (n=29) and HA (n=30) groups. Intramuscular etofenamate injection was administered as a series of seven intramuscular injections at intervals of 1 day. Intra-articular HA injection was administered as a series of three intra-articular injections at intervals of 1 week. Clinical evaluation was made before the first injection and again both 6 and 12 months after the last injection. The evaluation consisted of patient-assessed pain on a visual analog scale (VAS) and on the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC). Statistical significance was found for the etofenamate group when comparing preinjection with 12 months postinjection VAS scores (
ISSN:1176-6336
1178-203X
1178-203X
DOI:10.2147/TCRM.S114707