Serum soluble lectin‐like oxidized low‐density lipoprotein receptor‐1 as a biomarker of delayed cerebral ischemia after aneurysmal subarachnoid hemorrhage

Objective Delayed cerebral ischemia (DCI) greatly contributes to the high morbidity and mortality of aneurysmal subarachnoid hemorrhage (aSAH) patients. Expression of lectin‐like oxidized low‐density lipoprotein receptor‐1 (LOX‐1) was substantially raised in the basilar arterial wall of SAH rabbits....

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Bibliographic Details
Published in:Brain and behavior 2020-02, Vol.10 (2), p.e01517-n/a
Main Authors: Lin, Qun, Ba, Hua‐Jun, Dai, Jun‐Xia, Sun, Jun, Lu, Chuan, Chen, Mao‐Hua, Chen, Xian‐Dong, Cai, Jian‐Yong
Format: Article
Language:English
Subjects:
aneurysmal subarachnoid hemorrhage
Aneurysms
Biomarkers
Biomarkers - blood
Blood pressure
Brain Ischemia - blood
Brain Ischemia - etiology
delayed cerebral ischemia
Female
Hemorrhage
Humans
Intracranial Aneurysm - complications
Ischemia
Laboratories
Lectins
lectin‐like oxidized low‐density lipoprotein receptor‐1
Lipoproteins
Male
Medical imaging
Middle Aged
Original Research
Pathogenesis
Patients
Prognosis
Scavenger Receptors, Class E - blood
severity
Severity of Illness Index
Statistical analysis
Stroke
Studies
Subarachnoid Hemorrhage - complications
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Summary:Objective Delayed cerebral ischemia (DCI) greatly contributes to the high morbidity and mortality of aneurysmal subarachnoid hemorrhage (aSAH) patients. Expression of lectin‐like oxidized low‐density lipoprotein receptor‐1 (LOX‐1) was substantially raised in the basilar arterial wall of SAH rabbits. We attempted to ascertain the relationship between serum soluble LOX‐1 (sLOX‐1) levels and the occurrence of DCI after aSAH. Materials and methods We enrolled 125 aSAH patients and 125 healthy controls. Serum sLOX‐1 levels were quantified using commercial enzyme‐linked immunosorbent assay kit. The relationship between sLOX‐1 levels and DCI was analyzed utilizing the multivariate logistic regression analysis. Results Serum sLOX‐1 levels were significantly higher in stroke patients than in controls (median: 1,450.2 vs. 445.7 pg/ml, p  1,450.2 pg/ml, WFNS scores and modified Fisher scores were the independent predictors of DCI. Under receiver operating characteristic curve, serum sLOX‐1 levels exhibited a significant discriminatory capability (area under curve 0.825, 95% confidence interval 0.747–0.887). The predictive power of serum sLOX‐1 levels was similar to those of WFNS scores and modified Fisher grade (both p > .05). Moreover, serum sLOX‐1 levels significantly improved their predictive capability (both p 
ISSN:2162-3279
2162-3279
DOI:10.1002/brb3.1517