Antibiofilm Activity of Polyamide 11 Modified with Thermally Stable Polymeric Biocide Polyhexamethylene Guanidine 2-Naphtalenesulfonate

• Published in: International journal of molecular sciences 2019-01, Vol.20 (2), p.348
• Main Authors: Moshynets, Olena, Bardeau, Jean-François, Tarasyuk, Oksana, Makhno, Stanislav, Cherniavska, Tetiana, Dzhuzha, Oleg, Potters, Geert, Rogalsky, Sergiy
• Format: Article
• Language: English
• Subjects: Additives; Anion exchanging; antibacterial; Antibiotics; Antiinfectives and antibacterials; Antimicrobial agents; Bacteria; Biocides; Biocompatibility; Biodegradation; biofilm; Biofilms; Cell membranes; Chemical Physics; Contamination; Copper; Copper compounds; E coli; Electrostatic properties; Engineering Sciences; Formulations; General Physics; Guanidine; Leaching; Materials; Mechanical properties; Medical equipment; Microorganisms; Nanoparticles; Odors; Phospholipids; Physics; polyamide 11; Polyamide resins; Polyamides; polymeric biocide; Polymers; Resins; Silver; Silver compounds; Spectrum analysis; Thermal stability; Toxicity
• ISSN: 1422-0067; 1661-6596; 1422-0067
• DOI: 10.3390/ijms20020348

The choice of efficient antimicrobial additives for polyamide resins is very difficult because of their high processing temperatures of up to 300 °C. In this study, a new, thermally stable polymeric biocide, polyhexamethylene guanidine 2-naphtalenesulfonate (PHMG-NS), was synthesised. According to thermogravimetric analysis, PHMG-NS has a thermal degradation point of 357 °C, confirming its potential use in joint melt processing with polyamide resins. Polyamide 11 (PA-11) films containing 5, 7 and 10 wt% of PHMG-NS were prepared by compression molding and subsequently characterised by FTIR spectroscopy. The surface properties were evaluated both by contact angle, and contactless induction. The incorporation of 10 wt% of PHMG-NS into PA-11 films was found to increase the positive surface charge density by almost two orders of magnitude. PA-11/PHMG-NS composites were found to have a thermal decomposition point at about 400 °C. Mechanical testing showed no change of the tensile strength of polyamide films containing PHMG-NS up to 7 wt%. Antibiofilm activity against the opportunistic bacteria and was demonstrated for films containing 7 or 10 wt% of PHMG-NS, through a local biocide effect possibly based on an influence on the bacterial eDNA. The biocide hardly leached from the PA-11 matrix into water, at a rate of less than 1% from its total content for 21 days.