Oxidative stress in carotid arteries of patients submitted to carotid endarterectomy. The role of aging process

ABSTRACT PURPOSE: To evaluated the role of oxidative stress on aging process in patients submitted to carotid endarterectomy. METHODS: Twenty patients were divided into two groups: older group (≥ 70 years old); and the younger group (< 70 years old). We evaluated the reactive oxygen species (ROS)...

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Bibliographic Details
Published in:Acta cirúrgica brasileira 2016-08, Vol.31 (8), p.564-568
Main Authors: Lucas, Márcio Luís, Carraro, Cristina Campos, Belló-Klein, Adriane, Kalil, Antônio Nocchi, Aerts, Newton
Format: Article
Language:English
Subjects:
Carotid
Oxidative Stress. Reactive Oxygen Species. Carotid Arteries. Endarterectomy
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Summary:ABSTRACT PURPOSE: To evaluated the role of oxidative stress on aging process in patients submitted to carotid endarterectomy. METHODS: Twenty patients were divided into two groups: older group (≥ 70 years old); and the younger group (< 70 years old). We evaluated the reactive oxygen species (ROS) concentration, nicotinamide adenine dinucleotide phosphate (NADPH)-oxidase, superoxide dismutase (SOD) and catalase (CAT) activities as so as nitrite levels in fragments of carotid arteries harvested during carotid endarterectomy for treatment of high grade carotid stenosis. RESULTS: We observed a higher levels of ROS and NADPH oxidase activity in the older group (p
ISSN:0102-8650
0102-8650
DOI:10.1590/S0102-865020160080000010