Oxidative stress in carotid arteries of patients submitted to carotid endarterectomy. The role of aging process

ABSTRACT PURPOSE: To evaluated the role of oxidative stress on aging process in patients submitted to carotid endarterectomy. METHODS: Twenty patients were divided into two groups: older group (≥ 70 years old); and the younger group (< 70 years old). We evaluated the reactive oxygen species (ROS)...

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Published in:Acta cirúrgica brasileira 2016-08, Vol.31 (8), p.564-568
Main Authors: Lucas, Márcio Luís, Carraro, Cristina Campos, Belló-Klein, Adriane, Kalil, Antônio Nocchi, Aerts, Newton
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Language:English
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Carotid
Oxidative Stress. Reactive Oxygen Species. Carotid Arteries. Endarterectomy
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container_title Acta cirúrgica brasileira
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description ABSTRACT PURPOSE: To evaluated the role of oxidative stress on aging process in patients submitted to carotid endarterectomy. METHODS: Twenty patients were divided into two groups: older group (≥ 70 years old); and the younger group (< 70 years old). We evaluated the reactive oxygen species (ROS) concentration, nicotinamide adenine dinucleotide phosphate (NADPH)-oxidase, superoxide dismutase (SOD) and catalase (CAT) activities as so as nitrite levels in fragments of carotid arteries harvested during carotid endarterectomy for treatment of high grade carotid stenosis. RESULTS: We observed a higher levels of ROS and NADPH oxidase activity in the older group (p
doi_str_mv 10.1590/S0102-865020160080000010
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The role of aging process</title><source>SciELO Brazil</source><creator>Lucas, Márcio Luís ; Carraro, Cristina Campos ; Belló-Klein, Adriane ; Kalil, Antônio Nocchi ; Aerts, Newton</creator><creatorcontrib>Lucas, Márcio Luís ; Carraro, Cristina Campos ; Belló-Klein, Adriane ; Kalil, Antônio Nocchi ; Aerts, Newton</creatorcontrib><description>ABSTRACT PURPOSE: To evaluated the role of oxidative stress on aging process in patients submitted to carotid endarterectomy. METHODS: Twenty patients were divided into two groups: older group (≥ 70 years old); and the younger group (&lt; 70 years old). We evaluated the reactive oxygen species (ROS) concentration, nicotinamide adenine dinucleotide phosphate (NADPH)-oxidase, superoxide dismutase (SOD) and catalase (CAT) activities as so as nitrite levels in fragments of carotid arteries harvested during carotid endarterectomy for treatment of high grade carotid stenosis. RESULTS: We observed a higher levels of ROS and NADPH oxidase activity in the older group (p&lt;0.05). Furthermore, the nitrite concentration was lower in the older group (14.55 ± 5.61 x 10-3 versus 26.42 ± 8.14 x 10-3 µM; p=0.0123). However, the activities of antioxidant enzymes (CAT and SOD) were similar in both the groups. CONCLUSIONS : Arterial aging is associated with increased concentrations of oxygen species and nicotinamide adenine dinucleotide phosphate (NADPH) oxidase activity as so as nitrite reduction in human carotid artery specimens. 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CONCLUSIONS : Arterial aging is associated with increased concentrations of oxygen species and nicotinamide adenine dinucleotide phosphate (NADPH) oxidase activity as so as nitrite reduction in human carotid artery specimens. Maybe therapies that block NADPH oxidase activity and enhance nitrite stores would be a good strategy to reduce the effect of oxidative stress in arterial aging.</description><subject>Carotid</subject><subject>Oxidative Stress. Reactive Oxygen Species. Carotid Arteries. 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subjects Carotid
Oxidative Stress. Reactive Oxygen Species. Carotid Arteries. Endarterectomy
title Oxidative stress in carotid arteries of patients submitted to carotid endarterectomy. The role of aging process
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