Search for structurally diverse heterocyclic analogs as dual-acting antimalarial and antileishmanial agents: An overview

Infections caused by protozoan parasites continue to be a significant cause of morbidity and mortality across the globe, with malaria and leishmaniasis forming the fulcrum of these infections. Decreased effectiveness of existing drugs and increasing cases of drug resistance have called for a multifa...

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Published in:European journal of medicinal chemistry reports 2022-04, Vol.4, p.100031, Article 100031
Main Authors: Faheem, Dey, Sanchita, Johri, Samridhi, Abirami, M., Kumar, Banoth Karan, Taramelli, Donatella, Basilico, Nicoletta, Balana-Fouce, Rafael, Gowri Chandra Sekhar, Kondapalli Venkata, Murugesan, Sankaranarayanan
Format: Article
Language:English
Subjects:
Amastigotes
Dual-acting
Heterocyclics
Leishmania spp
Leishmaniasis
Malaria
Plasmodium spp
Promastigotes
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Summary:Infections caused by protozoan parasites continue to be a significant cause of morbidity and mortality across the globe, with malaria and leishmaniasis forming the fulcrum of these infections. Decreased effectiveness of existing drugs and increasing cases of drug resistance have called for a multifaceted approach for the development of safe, efficacious, and affordable drugs for malaria and leishmaniasis. The present review article aims to unearth structurally diverse compounds as dual-acting antimalarial and antileishmanial agents. The current review article mainly focuses on the structure, biological activities, and structure-activity relationship (SAR) studies of synthetic and natural compounds that showed promising potential against malaria and Leishmania parasites in the past decade (2011–2021). [Display omitted]
ISSN:2772-4174
2772-4174
DOI:10.1016/j.ejmcr.2022.100031