The Role of Lytic Infection for Lymphomagenesis of Human γ-Herpesviruses

Epstein Barr virus (EBV) and Kaposi sarcoma associated herpesvirus (KSHV) are two oncogenic human γ-herpesviruses that are each associated with 1-2% of human tumors. They encode bona fide oncogenes that they express during latent infection to amplify their host cells and themselves within these. In...

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Bibliographic Details
Published in:Frontiers in cellular and infection microbiology 2021-03, Vol.11, p.605258-605258
Main Author: Münz, Christian
Format: Article
Language:English
Subjects:
Cellular and Infection Microbiology
early lytic EBV antigen specific T cells
Epstein Barr virus
Kaposi sarcoma associated herpesvirus
viral G-protein coupled receptor
viral IL-10
viral IL-6
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Summary:Epstein Barr virus (EBV) and Kaposi sarcoma associated herpesvirus (KSHV) are two oncogenic human γ-herpesviruses that are each associated with 1-2% of human tumors. They encode bona fide oncogenes that they express during latent infection to amplify their host cells and themselves within these. In contrast, lytic virus particle producing infection has been considered to destroy host cells and might be even induced to therapeutically eliminate EBV and KSHV associated tumors. However, it has become apparent in recent years that early lytic replication supports tumorigenesis by these two human oncogenic viruses. This review will discuss the evidence for this paradigm change and how lytic gene products might condition the microenvironment to facilitate EBV and KSHV associated tumorigenesis.
ISSN:2235-2988
2235-2988
DOI:10.3389/fcimb.2021.605258