A Structural and Functional Perspective of Death Receptor 6

As a member of the tumor necrosis factor receptor superfamily (TNFRSF), death receptor 6 (DR6) has a similar structural architecture to other family members. The extracellular region of DR6 contains four cysteine-rich domains, followed by a single-pass transmembrane domain and an intracellular regio...

Full description

Saved in:
Bibliographic Details
Published in:Frontiers in pharmacology 2022-03, Vol.13, p.836614
Main Authors: Ren, Xiuying, Lin, Zhi, Yuan, Wensu
Format: Article
Language:English
Subjects:
co-receptor
death domain
death receptor
DR6
Pharmacology
signaling
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:As a member of the tumor necrosis factor receptor superfamily (TNFRSF), death receptor 6 (DR6) has a similar structural architecture to other family members. The extracellular region of DR6 contains four cysteine-rich domains, followed by a single-pass transmembrane domain and an intracellular region. Since its discovery, DR6 has become an orphan receptor ubiquitously expressed to transduce unique signaling pathways. Although the free ectodomains of β-amyloid precursor protein (APP) can bind to DR6 to induce apoptotic signals, the natural ligands of DR6 still remain largely unknown. In this review, we focus on recent research progress of structural and functional studies on DR6 for better understanding DR6-mediated signaling and the treatment of DR6-related diseases.
ISSN:1663-9812
1663-9812
DOI:10.3389/fphar.2022.836614