Molecular Crosstalk between Chromatin Remodeling and Tumor Microenvironment in Multiple Myeloma

Multiple myeloma (MM) is a complex disease driven by numerous genetic and epigenetic alterations that are acquired over time. Despite recent progress in the understanding of MM pathobiology and the availability of innovative drugs, which have pronounced clinical outcome, this malignancy eventually p...

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Bibliographic Details
Published in:Current oncology (Toronto) 2022-12, Vol.29 (12), p.9535-9549
Main Authors: Chakraborty, Chandraditya, Mukherjee, Srimoyee
Format: Article
Language:English
Subjects:
Analysis
B cells
Bone Marrow - metabolism
Bone Marrow - pathology
Cancer
Chromatin
Chromatin Assembly and Disassembly
chromatin remodeling
Development and progression
Drug resistance
Ecosystem
Epigenetic inheritance
Gene expression
Genetic aspects
Health aspects
Humans
Multiple myeloma
Multiple Myeloma - drug therapy
Review
tumor microenvironment
Tumor Microenvironment - genetics
Tumors
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Description
Summary:Multiple myeloma (MM) is a complex disease driven by numerous genetic and epigenetic alterations that are acquired over time. Despite recent progress in the understanding of MM pathobiology and the availability of innovative drugs, which have pronounced clinical outcome, this malignancy eventually progresses to a drug-resistant lethal stage and, thus, novel therapeutic drugs/models always play an important role in effective management of MM. Modulation of tumor microenvironment is one of the hallmarks of cancer biology, including MM, which affects the myeloma genomic architecture and disease progression subtly through chromatin modifications. The bone marrow niche has a prime role in progression, survival, and drug resistance of multiple myeloma cells. Therefore, it is important to develop means for targeting the ecosystem between multiple myeloma bone marrow microenvironment and chromatin remodeling. Extensive gene expression profile analysis has indeed provided the framework for new risk stratification of MM patients and identifying novel molecular targets and therapeutics. However, key tumor microenvironment factors/immune cells and their interactions with chromatin remodeling complex proteins that drive MM cell growth and progression remain grossly undefined.
ISSN:1718-7729
1198-0052
1718-7729
DOI:10.3390/curroncol29120749