Mechanisms of Chronic Metabolic Stress in Arrhythmias

Cardiac arrhythmias are responsible for many cardiovascular disease-related deaths worldwide. While arrhythmia pathogenesis is complex, there is increasing evidence for metabolic causes. Obesity, diabetes, and chronically consuming high-fat foods significantly increase the likelihood of developing a...

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Bibliographic Details
Published in:Antioxidants 2020-10, Vol.9 (10), p.1012
Main Authors: Gowen, Blake H., Reyes, Michael V., Joseph, Leroy C., Morrow, John P.
Format: Article
Language:English
Subjects:
Antioxidants
Arrhythmia
Cardiac arrhythmia
Cardiomyocytes
Cardiovascular disease
Cardiovascular diseases
Diabetes
Diabetes mellitus
Diet
Enzymes
Experiments
Fatty acids
Food
Heart failure
High fat diet
high-fat diet (HFD)
Kinases
Metabolism
Mitochondria
myocardium
Obesity
Observations
Oils & fats
Oxidation
Oxidative stress
Physiological aspects
Review
Trans fats
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Summary:Cardiac arrhythmias are responsible for many cardiovascular disease-related deaths worldwide. While arrhythmia pathogenesis is complex, there is increasing evidence for metabolic causes. Obesity, diabetes, and chronically consuming high-fat foods significantly increase the likelihood of developing arrhythmias. Although these correlations are well established, mechanistic explanations connecting a high-fat diet (HFD) to arrhythmogenesis are incomplete, although oxidative stress appears to be critical. This review investigates the metabolic changes that occur in obesity and after HFD. Potential therapies to prevent or treat arrhythmias are discussed, including antioxidants.
ISSN:2076-3921
2076-3921
DOI:10.3390/antiox9101012