A case of thrombotic thrombocytopenic purpura induced by acute pancreatitis

Thrombotic thrombocytopenic purpura (TTP) is a multisystemic microvascular disorder that may be caused by an imbalance between unusually large von Willebrand factor multimers and the cleaving protease ADAMTS13. In acquired TTP, especially in secondary TTP with various underlying diseases, the diagno...

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Bibliographic Details
Published in:International journal of general medicine 2012-01, Vol.5 (default), p.307-311
Main Authors: Arimoto, Miyoko, Komiyama, Yutaka, Okamae, Fumiko, Ichibe, Akemi, Teranishi, Setsuko, Tokunaga, Hirohiko, Nakaya, Keiko, Fujiwara, Michie, Yamaoka, Manabu, Onishi, Shuji, Miyamoto, Rie, Nakamichi, Naoto, Nomura, Shosaku
Format: Article
Language:English
Subjects:
acute pancreatitis
ADAMTS13
Care and treatment
Case Report
Case studies
Complications and side effects
Diagnosis
Health aspects
Health risk assessment
Hematopoietic stem cells
Pancreatitis
Patient outcomes
plasma exchange
Risk factors
Thrombocytopenic purpura
thrombotic thrombocytopenic purpura
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Summary:Thrombotic thrombocytopenic purpura (TTP) is a multisystemic microvascular disorder that may be caused by an imbalance between unusually large von Willebrand factor multimers and the cleaving protease ADAMTS13. In acquired TTP, especially in secondary TTP with various underlying diseases, the diagnosis is difficult because there are many cases that do not exhibit severe deficiency of ADAMTS13 or raised levels of ADAMST13 inhibitors. It is well known that collagen disease, malignancy, and hematopoietic stem cell transplantation can be underlying conditions that induce TTP. However, TTP induced by acute pancreatitis, as experienced by our patient, has rarely been reported. Our patient completely recovered with treatments using steroids and plasma exchange (PE) only. In cases where patients develop acute pancreatitis with no apparent causes for hemolytic anemia and thrombocytopenia, the possibility of TTP should be considered. Treatments for TTP including PE should be evaluated as soon as a diagnosis is made.
ISSN:1178-7074
1178-7074
DOI:10.2147/IJGM.S30271