IgG Antibodies Generation and Side Effects Caused by Ad5-nCoV Vaccine (CanSino Biologics) and BNT162b2 Vaccine (Pfizer/BioNTech) among Mexican Population

SARS-CoV-2 has rapidly generated a pandemic. Vaccines are currently being rolled out to control the viral spread and prevent deaths. Emergency vaccines, using new platforms, have been approved. Their effectiveness, safety and immunogenicity in different populations are not fully known. This study ai...

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Bibliographic Details
Published in:Vaccines (Basel) 2021-09, Vol.9 (9), p.999
Main Authors: Guzmán-Martínez, Oscar, Guardado, Kathia, de Guevara, Elsa Ladrón, Navarro, Saturnino, Hernández, Crescencio, Zenteno-Cuevas, Roberto, Montero, Hilda
Format: Article
Language:English
Subjects:
Ad5-nCoV
adverse effects
Age
Antibodies
BNT162b2
Coronaviruses
Correlation analysis
COVID-19 vaccines
Enzyme-linked immunosorbent assay
FDA approval
IgG antibody
Immunization
Immunogenicity
Immunoglobulin G
Infections
Medical research
mRNA
Overweight
Pandemics
Population
Preventable deaths
Protein S
Proteins
Public health
Ribonucleic acid
RNA
SARS-CoV-2
Severe acute respiratory syndrome coronavirus 2
Side effects
Vaccines
Viral diseases
Womens health
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Summary:SARS-CoV-2 has rapidly generated a pandemic. Vaccines are currently being rolled out to control the viral spread and prevent deaths. Emergency vaccines, using new platforms, have been approved. Their effectiveness, safety and immunogenicity in different populations are not fully known. This study aimed to discover the immunogenicity of the messenger ribonucleic acid (mRNA) BNT162b2 and adenovirus vector Ad5-nCoV vaccines through IgG antibody generation against subunit 1 of protein S (S1 IgG) and assess the side effects of the vaccines. A total of 115 vaccinated people were included, 61 of whom received the BNT162b2 vaccine, while 54 received Ad5-nCoV. Measurements of S1 IgG antibodies were carried out using the enzyme-linked immunosorbent assay (ELISA) technique. The BNT162b2 vaccine generated S1 IgG antibodies in 80.3% of the participants after the first dose. The number of seropositive participants increased to 98.36% with the administration of the second dose. The Ad5-nCoV vaccine generated S1 IgG antibodies in 88.89% of those vaccinated. Women generated more antibodies when administered either vaccine. There were no serious adverse effects from vaccination. In conclusion, not all participants had detectable S1 IgG antibodies. The Ad5-nCoV vaccine presented the most seronegative cases. The studied vaccines were shown to be safe.
ISSN:2076-393X
2076-393X
DOI:10.3390/vaccines9090999