A comparison between the effect of trans-anethole and metformin on biochemical parameters of polycystic ovary syndrome in rats

The effect of trans-anethole and metformin on biochemical and hormonal changes of testosterone-induced Polycystic ovary syndrome (PCOS) in rats was investigated. Female Wister rats (n=48) were randomly divided into six groups: control; PCOS; PCOS+metformin (300 mg/kg); and PCOS+trans-anethole (20, 4...

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Bibliographic Details
Published in:Avicenna journal of phytomedicine 2021-09, Vol.11 (5), p.484-493
Main Authors: Moradi Negahdari, Faezeh, Hadjzadeh, Mousa-Al-Reza, Gholamnezhad, Zahra, Samadi Noshahr, Zahra, Keshavarzi, Zakieh
Format: Article
Language:English
Subjects:
dehydroepiandrosterone
insulin
metformin
Original
pcos
testosterone
trans-anethole
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Summary:The effect of trans-anethole and metformin on biochemical and hormonal changes of testosterone-induced Polycystic ovary syndrome (PCOS) in rats was investigated. Female Wister rats (n=48) were randomly divided into six groups: control; PCOS; PCOS+metformin (300 mg/kg); and PCOS+trans-anethole (20, 40, and 80 mg/kg). PCOS was induced by intraperitoneal injection of testosterone (1 mg/kg/day) for 35 days. After induction of PCOS, trans-anethole and metformin were given orally for 30 days. Finally, blood sugar, insulin, lipid profile, and testosterone and dehydroepiandrosterone (DHEAS) as well as animals' weight, and water and food intake were determined. In all treated and untreated PCOS groups, serum testosterone levels were significantly increased compared to the control group (p
ISSN:2228-7930
2228-7949
DOI:10.22038/AJP.2021.55679.2785