Induction of Plasmodium-Specific Immune Responses Using Liposome-Based Vaccines

In the development of vaccines, the ability to initiate both innate and subsequent adaptive immune responses need to be considered. Live attenuated vaccines achieve this naturally, while inactivated and sub-unit vaccines generally require additional help provided through delivery systems and/or adju...

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Bibliographic Details
Published in:Frontiers in immunology 2019-02, Vol.10, p.135-135
Main Authors: Ssemaganda, Aloysious, Giddam, Ashwini Kumar, Zaman, Mehfuz, Skwarczynski, Mariusz, Toth, Istvan, Stanisic, Danielle I, Good, Michael F
Format: Article
Language:English
Subjects:
adjuvant
Animals
Humans
immunity
Immunology
Liposomes
malaria
Malaria Vaccines - administration & dosage
Plasmodium
Plasmodium - immunology
vaccine
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Summary:In the development of vaccines, the ability to initiate both innate and subsequent adaptive immune responses need to be considered. Live attenuated vaccines achieve this naturally, while inactivated and sub-unit vaccines generally require additional help provided through delivery systems and/or adjuvants. Liposomes present an attractive adjuvant/delivery system for antigens. Here, we review the key aspects of immunity against parasites, liposome design considerations and their current application in the development of a malaria vaccine.
ISSN:1664-3224
1664-3224
DOI:10.3389/fimmu.2019.00135