Inflammation and DNA methylation in Alzheimer's disease: mechanisms of epigenetic remodelling by immune cell oxidants in the ageing brain

Alzheimer's disease is a neurodegenerative disease involving memory impairment, confusion, and behavioural changes. The disease is characterised by the accumulation of amyloid beta plaques and neurofibrillary tangles in the brain, which disrupt normal neuronal function. There is no known cure f...

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Bibliographic Details
Published in:Redox report : communications in free radical research 2024-12, Vol.29 (1), p.2428152
Main Authors: Seddon, A R, MacArthur, C P, Hampton, M B, Stevens, A J
Format: Article
Language:English
Subjects:
Aging
Alzheimer Disease - genetics
Alzheimer Disease - immunology
Alzheimer Disease - metabolism
Alzheimer’s disease
Animals
Brain - metabolism
DNA Methylation
Epigenesis, Genetic
Epigenetics
Humans
Inflammation - genetics
Inflammation - metabolism
microglia
myeloperoxidase
neuroinflammation
neutrophils
Oxidants - metabolism
Oxidative Stress
Review
Citations: Items that this one cites
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Summary:Alzheimer's disease is a neurodegenerative disease involving memory impairment, confusion, and behavioural changes. The disease is characterised by the accumulation of amyloid beta plaques and neurofibrillary tangles in the brain, which disrupt normal neuronal function. There is no known cure for Alzheimer's disease and due to increasing life expectancy, occurrence is projected to rise over the coming decades. The causes of Alzheimer's disease are multifactorial with inflammation, oxidative stress, genetic and epigenetic variation, and cerebrovascular abnormalities among the strongest contributors. We review the current literature surrounding inflammation and epigenetics in Alzheimer's disease, with a focus on how oxidants from infiltrating immune cells have the potential to alter DNA methylation profiles in the ageing brain.
ISSN:1351-0002
1743-2928
1743-2928
DOI:10.1080/13510002.2024.2428152