Anticancer Effects of Cold Atmospheric Plasma in Canine Osteosarcoma Cells

Osteosarcoma is known to be one of the frequently occurring cancers in dogs. Its prognosis is usually very poor, with a high incidence of lung metastasis. Although radiation therapy has become a major therapeutic choice for canine osteosarcoma, the high costs and unexpected side effects prevent some...

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Bibliographic Details
Published in:International journal of molecular sciences 2020-06, Vol.21 (12), p.4556
Main Authors: Lee, Jaehak, Moon, Hyunjin, Ku, Bonghye, Lee, Keunho, Hwang, Cheol-Yong, Baek, Seung Joon
Format: Article
Language:English
Subjects:
Animals
Antineoplastic Agents - pharmacology
Antitumor activity
Apoptosis
Biomedical materials
Bone cancer
Bone Neoplasms - drug therapy
Bone Neoplasms - metabolism
Bone Neoplasms - pathology
Cancer therapies
canine osteosarcoma
Cell growth
Cell Movement
Cell Proliferation
Cold
cold atmospheric plasma
Cold treatment
Dogs
Flow cytometry
high-content screening
Low temperature
Metastases
metastasis
Osteosarcoma
Osteosarcoma - drug therapy
Osteosarcoma - metabolism
Osteosarcoma - pathology
Osteosarcoma cells
Plasma Gases - pharmacology
Radiation therapy
Reactive oxygen species
Reactive Oxygen Species - metabolism
Sarcoma
Signal Transduction
Tumor Cells, Cultured
Veterinary medicine
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Summary:Osteosarcoma is known to be one of the frequently occurring cancers in dogs. Its prognosis is usually very poor, with a high incidence of lung metastasis. Although radiation therapy has become a major therapeutic choice for canine osteosarcoma, the high costs and unexpected side effects prevent some patients from considering this treatment. Cold atmospheric plasma (CAP) is an ionized gas with high energy at low temperatures, and it produces reactive oxygen species that mediate many signaling pathways. Although many researchers have used CAP as an anticancer therapeutic approach in humans, its importance has been neglected in veterinary medicine. In this study, D-17 and DSN canine osteosarcoma cell lines were treated with CAP to observe its anticancer activity. By high-content screening and flow cytometry, CAP-treated cells showed growth arrest and apoptosis induction. Moreover, the osteosarcoma cells exhibited reduced migration and invasion activity when treated with CAP. Overall, CAP exerted an anticancer effect on canine osteosarcoma cell lines. CAP may have the potential to be used as a novel modality for treating cancer in veterinary medicine.
ISSN:1422-0067
1661-6596
1422-0067
DOI:10.3390/ijms21124556