Beneficial Effects of Prebiotic Saccharomyces cerevisiae Mannan on Allergic Asthma Mouse Models

One of the unmet needs for asthma management is a new therapeutic agent with both anti-inflammatory and anti-smooth muscle (ASM) remodeling effects. The mannose receptor (MR) family plays an important role in allergen uptake and processing of major allergens Der p 1 and Fel d 1. We have previously r...

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Bibliographic Details
Published in:Journal of immunology research 2017-01, Vol.2017 (2017), p.1-10
Main Authors: Samarasinghe, Amali E., Gaber, M. Waleed, LeMessurier, Kim S., Patel, Jennifer K., Lehman, Jeffrey M., Rohman, Erin L., Robinson, W. Scout, Overbeck, Tracie, Michael, Christie F., Lew, D. Betty, Eiseman, Brandi
Format: Article
Language:English
Subjects:
Airway Remodeling - drug effects
Allergens
Allergens - immunology
Allergies
Animal models
Animals
Antigens
Archives & records
Asthma
Asthma - prevention & control
Breweries
Cell growth
Cell proliferation
Chemical compounds
Cloning
Cloning, Molecular
Consortia
Dendritic cells
Der p 1 antigen
Disease Models, Animal
Humans
Hydrolase
Hyperplasia
Hypertrophy
Immunology
Inflammation
Laboratories
Lectins, C-Type - genetics
Lectins, C-Type - metabolism
Mannan
Mannans - administration & dosage
Mannose
Mannose Receptor
Mannose-Binding Lectins - genetics
Mannose-Binding Lectins - metabolism
Medicine
Membrane Glycoproteins - genetics
Membrane Glycoproteins - metabolism
Mice
Mice, Transgenic
Microorganisms
Muscle, Smooth - drug effects
Pediatrics
Prebiotics
Prebiotics - administration & dosage
Receptors, Cell Surface - genetics
Receptors, Cell Surface - metabolism
Rodents
Saccharomyces cerevisiae
Saccharomyces cerevisiae - chemistry
Smooth muscle
Transgenic animals
Transgenic mice
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Summary:One of the unmet needs for asthma management is a new therapeutic agent with both anti-inflammatory and anti-smooth muscle (ASM) remodeling effects. The mannose receptor (MR) family plays an important role in allergen uptake and processing of major allergens Der p 1 and Fel d 1. We have previously reported that ASM cells express a mannose receptor (ASM-MR) and that mannan derived from Saccharomyces cerevisiae (SC-MN) inhibits mannosyl-rich lysosomal hydrolase-induced bovine ASM cell proliferation. Using a humanized transgenic mouse strain (huASM-MRC2) expressing the human MRC2 receptor in a SM tissue-specific manner, we have demonstrated that ASM hyperplasia/hypertrophy can occur as early as 15 days after allergen challenge in this mouse model and this phenomenon is preventable with SC-MN treatment. This proof-of-concept study would facilitate future development of a potential asthma therapeutic agent with dual function of anti-inflammatory and anti-smooth muscle remodeling effects.
ISSN:2314-8861
2314-7156
DOI:10.1155/2017/3432701