Details of the antioxidant mechanism of hydroxycinnamic acids

Antioxidant activities and free radical-mediated DNA strand breakages of five hydroxycinnamic acids were examined. Kinetic analysis of a stable galvinoxy (GO•)-scavenging reaction of hydroxycinnamic acids demonstrated that the molecular structure and the reaction medium were two important factors af...

Full description

Saved in:
Bibliographic Details
Published in:Czech Journal of Food Sciences 2015-01, Vol.33 (3), p.210-216
Main Authors: SHANG, Ya-Jing, LIU, Bao-Yong, ZHAO, Meng-Meng
Format: Article
Language:English
Subjects:
Acetic acid
Antioxidants
DNA damage
dna strand breakage
Electron transfer
Ethyl acetate
Free radicals
Hydroxycinnamic acid
Methanol
Molecular structure
radical-scavenging activity
Reaction mechanisms
reaction mechanisms structure-activity relationship
Scavenging
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Antioxidant activities and free radical-mediated DNA strand breakages of five hydroxycinnamic acids were examined. Kinetic analysis of a stable galvinoxy (GO•)-scavenging reaction of hydroxycinnamic acids demonstrated that the molecular structure and the reaction medium were two important factors affecting the antioxidant mechanism and activity. In methanol, the kinetic process of the compounds, which have electron-donating groups (-OH, -OCH3) in the ortho- or para-position of 4-OH, was primarily governed by the sequential proton loss electron transfer (SPLET mechanism). While, in ethyl acetate, the reaction mechanism is predominantly direct hydrogen atom transfer (HAT mechanism). But for the compounds having only one hydroxyl, both in ethyl acetate and methanol, the reaction mechanism is only HAT. At the same time, the compound bearing o-diphenoxyl is not the most active one in our tested environment.
ISSN:1212-1800
1805-9317
DOI:10.17221/611/2014-CJFS