Mucinous Borderline Tumor Associated with Mesonephric-like Proliferation: Further Evidence for a Possible New Origin of Ovarian Mucinous Neoplasms

Some ovarian mucinous tumors are thought to originate from Brenner tumors and teratomas; however, data are limited on what could be the origin for the remaining tumors. We report a new case of ovarian mucinous borderline tumor/atypical proliferative mucinous tumor (MBT/APMT) co-existing with a meson...

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Published in:Diagnostics (Basel) 2022-08, Vol.12 (8), p.1901
Main Authors: Zhang, Jie, Dong, Yuling, Zhou, Xiaoqiu, Finkelman, Brian S, Xing, Deyin
Format: Article
Language:English
Subjects:
Cancer
Case Report
Case studies
Causes of
Cervix
Complications and side effects
Cysts
Development and progression
DNA sequencing
Endometrium
Hyperplasia
Maternal & child health
mesonephric-like proliferation
Morphology
mucinous borderline tumor
mucinous metaplasia
Mutation
Nucleotide sequencing
Ovarian tumors
Ovaries
ovary
Polymerase chain reaction
Teratoma
Tumors
Zhang Jie
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description Some ovarian mucinous tumors are thought to originate from Brenner tumors and teratomas; however, data are limited on what could be the origin for the remaining tumors. We report a new case of ovarian mucinous borderline tumor/atypical proliferative mucinous tumor (MBT/APMT) co-existing with a mesonephric-like proliferation (MLP)/mesonephric-like hyperplasia (MLH). The patient was a 58-year-old woman who presented with a pelvic mass and abdominal pain. Pathology demonstrated an 11 cm MBT/APMT in the left ovary. In addition, the tumor contained one focal area (
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We report a new case of ovarian mucinous borderline tumor/atypical proliferative mucinous tumor (MBT/APMT) co-existing with a mesonephric-like proliferation (MLP)/mesonephric-like hyperplasia (MLH). The patient was a 58-year-old woman who presented with a pelvic mass and abdominal pain. Pathology demonstrated an 11 cm MBT/APMT in the left ovary. In addition, the tumor contained one focal area (&lt;1% of total tumor volume) of MLP/hyperplasia adjacent to, or intimately admixed with, mucinous epithelium, with an immunophenotype of diffuse Pax8 and Gata3 expression and negative TTF-1, ER, and PR staining. Pax8 was also weakly positive in the MBT/APMT component. Some mesonephric-like glands partially exhibited gastrointestinal-type mucinous metaplasia/differentiation. A polymerase chain reaction (PCR)-based Sanger sequencing demonstrated that a KRAS G12V mutation was present in both MLP/MLH and MBT/APMT components, providing further evidence to support their clonal relationship. We previously reported a series of similar cases and demonstrated a novel association between MLP, mesonephric-like adenocarcinoma and ovarian mucinous tumor. It is conceivable that benign MLPs may have ability to differentiate to lineage-specific mucinous lesions, and, as such, they may serve as a possible new origin of some ovarian mucinous neoplasms; in particular, Pax8-positive tumors. 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subjects Cancer
Case Report
Case studies
Causes of
Cervix
Complications and side effects
Cysts
Development and progression
DNA sequencing
Endometrium
Hyperplasia
Maternal & child health
mesonephric-like proliferation
Morphology
mucinous borderline tumor
mucinous metaplasia
Mutation
Nucleotide sequencing
Ovarian tumors
Ovaries
ovary
Polymerase chain reaction
Teratoma
Tumors
Zhang Jie
title Mucinous Borderline Tumor Associated with Mesonephric-like Proliferation: Further Evidence for a Possible New Origin of Ovarian Mucinous Neoplasms
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