Cannabis and Inflammation in HIV: A Review of Human and Animal Studies

Persistent inflammation occurs in people with HIV (PWH) and has many downstream adverse effects including myocardial infarction, neurocognitive impairment and death. Because the proportion of people with HIV who use cannabis is high and cannabis may be anti-inflammatory, it is important to character...

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Bibliographic Details
Published in:Viruses 2021-08, Vol.13 (8), p.1521
Main Authors: Ellis, Ronald J, Wilson, Natalie, Peterson, Scott
Format: Article
Language:English
Subjects:
Animals
Anti-Inflammatory Agents
Biomarkers
Cannabinoids
Cannabis
Cannabis - immunology
Cognition
Cytokines
Cytomegalovirus
Disease Models, Animal
Endocannabinoid system
Enzymes
Gastrointestinal Microbiome - drug effects
gut barrier integrity
gut microbiota
Hepatitis C
HIV
HIV Infections - immunology
HIV Infections - physiopathology
Human immunodeficiency virus
Humans
Infections
Inflammation
Inflammation - complications
Inflammation - physiopathology
Inflammation - virology
Literature reviews
Marijuana
Mental depression
Morbidity
Myocardial infarction
Nervous system
Plasma
Review
Tetrahydrocannabinol
THC
Tumor necrosis factor-TNF
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Summary:Persistent inflammation occurs in people with HIV (PWH) and has many downstream adverse effects including myocardial infarction, neurocognitive impairment and death. Because the proportion of people with HIV who use cannabis is high and cannabis may be anti-inflammatory, it is important to characterize the impact of cannabis use on inflammation specifically in PWH. We performed a selective, non-exhaustive review of the literature on the effects of cannabis on inflammation in PWH. Research in this area suggests that cannabinoids are anti-inflammatory in the setting of HIV. Anti-inflammatory actions are mediated in many cases through effects on the endocannabinoid system (ECS) in the gut, and through stabilization of gut-blood barrier integrity. Cannabidiol may be particularly important as an anti-inflammatory cannabinoid. Cannabis may provide a beneficial intervention to reduce morbidity related to inflammation in PWH.
ISSN:1999-4915
1999-4915
DOI:10.3390/v13081521