Detection of a Yersinia pestis gene homologue in rodent samples

A homologue to a widely used genetic marker, pla, for Yersinia pestis has been identified in tissue samples of two species of rat (Rattus rattus and Rattus norvegicus) and of mice (Mus musculus and Apodemus sylvaticus) using a microarray based platform to screen for zoonotic pathogens of interest. S...

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Bibliographic Details
Published in:PeerJ (San Francisco, CA) CA), 2016-08, Vol.4, p.e2216-e2216, Article e2216
Main Authors: Giles, Timothy A, Greenwood, Alex D, Tsangaras, Kyriakos, Giles, Tom C, Barrow, Paul A, Hannant, Duncan, Abu-Median, Abu-Bakr, Yon, Lisa
Format: Article
Language:English
Subjects:
Deoxyribonucleic acid
DNA
DNA microarrays
Genes
Genetic aspects
Genetic markers
Genetics
Genomes
Health aspects
House mouse
Infectious diseases
Microarray
Microbiology
Molecular Biology
Mus musculus
Pathogens
Pla gene
Polymerase chain reaction
Rattus norvegicus
Rattus rattus
Rodents
Screening
Veterinary medicine
Yersinia pestis
Zoonoses
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Summary:A homologue to a widely used genetic marker, pla, for Yersinia pestis has been identified in tissue samples of two species of rat (Rattus rattus and Rattus norvegicus) and of mice (Mus musculus and Apodemus sylvaticus) using a microarray based platform to screen for zoonotic pathogens of interest. Samples were from urban locations in the UK (Liverpool) and Canada (Vancouver). The results indicate the presence of an unknown bacterium that shares a homologue for the pla gene of Yersinia pestis, so caution should be taken when using this gene as a diagnostic marker.
ISSN:2167-8359
2167-8359
DOI:10.7717/peerj.2216