Growing problem of multidrug-resistant enteric pathogens in Africa

Control of fecal-orally transmitted pathogens is inadequate in many developing countries, in particular, in sub-Saharan Africa. Acquired resistance to antimicrobial drugs is becoming more prevalent among Vibrio cholerae, Salmonella enteritidis, diarrheagenic Escherichia coli, and other pathogens in...

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Bibliographic Details
Published in:Emerging infectious diseases 2007-11, Vol.13 (11), p.1640-1646
Main Authors: Okeke, Iruka N, Aboderin, Oladiipo A, Byarugaba, Denis K, Ojo, Kayode K, Opintan, Japheth A
Format: Article
Language:English
Subjects:
Africa - epidemiology
antibiotic resistance
antimicrobial resistance
Cholera toxin
Communicable Diseases, Emerging - drug therapy
Communicable Diseases, Emerging - epidemiology
Communicable Diseases, Emerging - microbiology
Developing Countries
Disease transmission
Drug resistance in microorganisms
Drug Resistance, Multiple, Bacterial
enteric pathogens
Enterobacteriaceae - drug effects
Enterobacteriaceae Infections - drug therapy
Enterobacteriaceae Infections - epidemiology
Enterobacteriaceae Infections - microbiology
Escherichia coli
Health aspects
Humans
Infection
Pathogenic microorganisms
perspective
Salmonella enteritidis
sub-Saharan Africa
Tuberculosis
Vibrio cholerae
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Summary:Control of fecal-orally transmitted pathogens is inadequate in many developing countries, in particular, in sub-Saharan Africa. Acquired resistance to antimicrobial drugs is becoming more prevalent among Vibrio cholerae, Salmonella enteritidis, diarrheagenic Escherichia coli, and other pathogens in this region. The poor, who experience most of the infections caused by these organisms, bear the brunt of extended illness and exacerbated proportion of deaths brought about by resistance. Improved antimicrobial drug stewardship is an often cited, but inadequately implemented, intervention for resistance control. Resistance containment also requires improvements in infectious disease control, access to and quality assurance of antimicrobial agents, as well as diagnostic facilities. Structural improvements along these lines will also enhance disease prevention and control as well as rational antimicrobial drug use. Additionally, more research is needed to identify low-cost, high-impact interventions for resistance control.
ISSN:1080-6040
1080-6059
DOI:10.3201/eid1311.070674