A Contemporary Review of the Treatment Landscape and the Role of Predictive and Prognostic Biomarkers in Pancreatic Adenocarcinoma

Pancreatic cancer continues to represent one of the leading causes of cancer-related morbidity and mortality in the developed world. Over the past decade, novel systemic therapy combination regimens have contributed to clinically meaningful and statistically significant improvements in overall survi...

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Bibliographic Details
Published in:Canadian journal of gastroenterology & hepatology 2018-01, Vol.2018 (2018), p.1-10
Main Authors: Yu, Irene S., Cheung, Winson Y.
Format: Article
Language:English
Subjects:
Adenocarcinoma
Advance directives
Antigens
Biological markers
Biomarkers
Breast cancer
Cancer therapies
Care and treatment
Chemotherapy
Ipilimumab
Jurisdiction
Medical prognosis
Medical research
Metastasis
Morbidity
Mortality
Novels
Oncology
Pancreatic cancer
Patients
Pemetrexed
Prognosis
Review
Studies
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Summary:Pancreatic cancer continues to represent one of the leading causes of cancer-related morbidity and mortality in the developed world. Over the past decade, novel systemic therapy combination regimens have contributed to clinically meaningful and statistically significant improvements in overall survival as compared to conventional monotherapy. However, the prognosis for most patients remains guarded secondary to the advanced stages of disease at presentation. There is growing consensus that outcomes can be further optimized with the use of predictive and prognostic biomarkers whereby the former can be enriching for patients who would benefit from therapies and the latter can inform decision-making regarding the need and timing of advanced care planning. One of the challenges of current biomarkers is the lack of standardization across clinical practices such that comparability between jurisdictions can be difficult or even impossible. This inconsistency can impede widespread implementation of their use. In this review article, we provide a comprehensive overview of the contemporary treatment options for pancreatic cancer and we offer some insights into the existing landscape and future directions of biomarker development for this disease.
ISSN:2291-2789
2291-2797
DOI:10.1155/2018/1863535