Seroepidemiology of hepatitis B virus (HBV) and relationship to serum transaminase levels in Indian population

Hepatitis B virus (HBV) infection is a serious public health issue that must be addressed. The goal of this study was to investigate the correlation between serological status for hepatitis Be antigen (HBeAg)/anti-HBe, serum transaminase levels, and serum HBV-DNA in patients with chronic HBV infecti...

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Bibliographic Details
Published in:Journal of family medicine and primary care 2024-06, Vol.13 (6), p.2410-2415
Main Authors: Kumar, Manoj, Seema, Kumari, Kumar, Dinesh, Kumar, Abhay, Sharma, Ashok Kumar, Boipai, Manju, Rani, Aysha
Format: Article
Language:English
Subjects:
alanine aminotransferase (alt) levels
hepatitis b
hepatitis b virus dna
hepatitis be antigens
Original
serologic tests
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Summary:Hepatitis B virus (HBV) infection is a serious public health issue that must be addressed. The goal of this study was to investigate the correlation between serological status for hepatitis Be antigen (HBeAg)/anti-HBe, serum transaminase levels, and serum HBV-DNA in patients with chronic HBV infection. A retrospective observational study with 620 patients with persistent HBV infection (mean age, 36.35 years; 506 men) was conducted. All patients tested positive for hepatitis B surface antigen (HBsAg). Liver profile, HBeAg, and anti-HBe antibody tests were conducted for all patients. Additionally, serum HBV DNA was examined using a DNA assay in these individuals. Of 620 patients, 114 (18.39%) were HBeAg-positive and 506 (81.61%) HBeAg-negative. A detectable level of HBV DNA was found in 89.79% of HBeAg-positive/anti-HBe negative patients compared to HBeAg-negative/anti-HBe positive carriers 33.69% ( value
ISSN:2249-4863
2278-7135
DOI:10.4103/jfmpc.jfmpc_1746_23