High lactic acid levels in the brain contribute to the generation of focal slowing on the electroencephalogram

Focal slowing on the EEG is often associated with structural pathology of the brain. Despite the clinical significance of focal slowing, the actual electrochemical mechanisms underlying this EEG phenomenon are still poorly understood. This paper briefly reviews the role of lactate in the pathogenesi...

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Bibliographic Details
Published in:Frontiers in neurology 2024-04, Vol.15, p.1393274
Main Authors: Chegodaev, Dmitry Alexandrovich, Pavlova, Polina Alekseevna
Format: Article
Language:English
Subjects:
acidosis
electroencephalogram
epilepsy
focal slowing
lactate
Neurology
structural lesions
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Summary:Focal slowing on the EEG is often associated with structural pathology of the brain. Despite the clinical significance of focal slowing, the actual electrochemical mechanisms underlying this EEG phenomenon are still poorly understood. This paper briefly reviews the role of lactate in the pathogenesis of brain disorders that are primarily related to focal EEG slowing. An attempt is made to trace the hypothetical link between this EEG pattern and focal cerebral tissue lactacidosis.
ISSN:1664-2295
1664-2295
DOI:10.3389/fneur.2024.1393274