One-Year Evolution of Symptoms and Health Status of the COPD Multi-Dimensional Phenotypes: Results from the Follow-Up of the STORICO Observational Study

Describing the 1-year evolution of symptoms and health status in COPD patients enrolled in the STORICO study (observational study on characterization of 24-h symptoms in patients with COPD) classified in multidimensional phenotypes (m-phenotypes). In our previous study, we performed an exploratory f...

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Bibliographic Details
Published in:International journal of chronic obstructive pulmonary disease 2021-01, Vol.16, p.1007-1020
Main Authors: Incalzi, Raffaele Antonelli, Blasi, Francesco, Scichilone, Nicola, Zullo, Alessandro, Simoni, Lucia, Canonica, Giorgio Walter
Format: Article
Language:English
Subjects:
Analysis
Anxiety
Asthma
Chronic obstructive pulmonary disease
Circadian rhythm
Cluster analysis
Cohort analysis
cohort study
Comorbidity
Dyspnea
evolution
Follow-Up Studies
Health Status
Humans
Observational studies
Original Research
Patients
Phenotype
Pulmonary Disease, Chronic Obstructive - diagnosis
Pulmonary Disease, Chronic Obstructive - epidemiology
Pulmonary Disease, Chronic Obstructive - therapy
Quality of Life
quality of sleep
Questionnaires
real world
Sleep
Surveys and Questionnaires
Variables
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Summary:Describing the 1-year evolution of symptoms and health status in COPD patients enrolled in the STORICO study (observational study on characterization of 24-h symptoms in patients with COPD) classified in multidimensional phenotypes (m-phenotypes). In our previous study, we performed an exploratory factor analysis to identify clinical and pathophysiological variables having the greatest classificatory properties, followed by a cluster analysis to group patients into m-phenotypes (mild COPD (MC), mild emphysematous (ME), severe bronchitic (SB), severe emphysematous (SE), and severe mixed COPD (SMC)). COPD symptoms were recorded at baseline, 6-, and 12-month follow-up and their evolution was described as frequency of patients with always present, always absent, arising', 'no more present symptoms. QoL and quality of sleep were evaluated using the SGRQ and CASIS questionnaires, respectively. We analyzed 379 subjects (144 MC, 71 ME, 96 SB, 14 SE, 54 SMC). M-phenotypes were stable over time in terms of presence of symptoms and health status with selected differences in evolution of symptoms in mild vs severe m-phenotypes. Indeed, 28.1% SB, 50.0% SE and 24.1% SMC vs 0.7% MC and 5.6% ME with night-time symptoms at baseline had no more symptoms at 6-month (p-value night-time symptom evolution MC vs SB, SE, SMC and ME vs SB, SE, SMC
ISSN:1178-2005
1176-9106
1178-2005
DOI:10.2147/COPD.S289697