Can Previous Associations of Single Nucleotide Polymorphisms in the TLR2 , NOD1 , CXCR5 , and IL10 Genes in the Susceptibility to and Severity of Chlamydia trachomatis Infections Be Confirmed?

Clear inter-individual differences exist in the response to (CT) infections and reproductive tract complications in women. Host genetic variation like single nucleotide polymorphisms (SNPs) have been associated with differences in response to CT infection, and SNPs might be used as a genetic compone...

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Bibliographic Details
Published in:Pathogens (Basel) 2021-01, Vol.10 (1), p.48
Main Authors: Jukema, Jelmer B, Hoenderboom, Bernice M, van Benthem, Birgit H B, van der Sande, Marianne A B, de Vries, Henry J C, Hoebe, Christian J P A, Dukers-Muijrers, Nicole H T M, Bax, Caroline J, Morré, Servaas A, Ouburg, Sander
Format: Article
Language:English
Subjects:
Algorithms
Asymptomatic
Chlamydia
Chlamydia trachomatis
CXCR5 protein
Ectopic pregnancy
Fertility
Genes
Genetic diversity
Genetics
Genotype & phenotype
Infections
Infertility
Interleukin 1
Interleukin 10
Nod1 protein
Nucleotides
Pathology
Pelvic inflammatory disease
Pregnancy complications
Reproductive system
Sensitivity analysis
Serology
severity
Sexually transmitted diseases
Single-nucleotide polymorphism
SNP
STD
susceptibility
TLR2 protein
Toll-like receptors
Womens health
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Summary:Clear inter-individual differences exist in the response to (CT) infections and reproductive tract complications in women. Host genetic variation like single nucleotide polymorphisms (SNPs) have been associated with differences in response to CT infection, and SNPs might be used as a genetic component in a tubal-pathology predicting algorithm. Our aim was to confirm the role of four genes by investigating proven associated SNPs in the susceptibility and severity of a CT infection. A total of 1201 women from five cohorts were genotyped and analyzed for + 2477 G > A, + 32656 T -> GG, + 10950 T > C, and - 1082 A > G. Results confirmed that + 32656 T ->GG was associated with an increased risk of a symptomatic CT infection (OR: 1.9, 95%CI: 1.1-3.4, = 0.02), but we did not observe an association with late complications. - 1082 A > G appeared to increase the risk of late complications (i.e., ectopic pregnancy/tubal factor infertility) following a CT infection (OR = 2.8, 95%CI: 1.1-7.1, = 0.02). Other associations were not found. Confirmatory studies are important, and large cohorts are warranted to further investigate SNPs' role in the susceptibility and severity of a CT infection.
ISSN:2076-0817
2076-0817
DOI:10.3390/pathogens10010048