An Effective Synthesis of Previously Unknown 7-Aryl Substituted Paullones

A straightforward three-step procedure affording a wide range of novel 7-aryl substituted paullone derivatives was developed. This scaffold is structurally similar to 2-(1 -indol-3-yl)acetamides-promising antitumor agents-hence, could be useful for the development of a new class of anticancer drugs.

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Bibliographic Details
Published in:Molecules (Basel, Switzerland) Switzerland), 2023-03, Vol.28 (5), p.2324
Main Authors: Aksenov, Dmitrii A, Akulova, Alesia S, Aleksandrova, Elena A, Aksenov, Nicolai A, Leontiev, Alexander V, Aksenov, Alexander V
Format: Article
Language:English
Subjects:
Acids
Alzheimer's disease
anticancer drug discovery
Aromatic compounds
Chromatography
Drug development
Fisher indolization
Metabolism
paullones synthesis
Solvents
Substitutes
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Description
Summary:A straightforward three-step procedure affording a wide range of novel 7-aryl substituted paullone derivatives was developed. This scaffold is structurally similar to 2-(1 -indol-3-yl)acetamides-promising antitumor agents-hence, could be useful for the development of a new class of anticancer drugs.
ISSN:1420-3049
1420-3049
DOI:10.3390/molecules28052324