The water extract of Korean Filipendula glaberrima Nakai attenuates acute colitis by suppressing inflammation via the MAPK and NF-κB pathways

• Published in: Journal of functional foods 2023-07, Vol.106, p.105606, Article 105606
• Main Authors: Jung, Jaemee, Hong, Mijin, Hwang, Dahyun
• Format: Article
• Language: English
• Subjects: Anti-inflammatory; Colitis; Dextran sulfate sodium; Filipendula glaberrima Nakai; RAW264.7
• ISSN: 1756-4646; 2214-9414
• DOI: 10.1016/j.jff.2023.105606

[Display omitted] •Filipendula glaberrima Nakai (FG) is a perennial plant in Korea and it is known to contain a variety of flavonoids.•The water extract of FG (FGW) reduced inflammatory cytokines via regulating MAPK and NF-κB signaling pathways in LPS-stimulated macrophages in vitro.•Administration of FGW improved the clinical symptoms of inflammation and repaired the damaged epithelium DSS-induced colitis mice in vivo.•FGW could be a potential treatment of colitis, either alone or as a supplement to other therapies. Colitis means inflammation of colon. For the safe treatment of colitis, drugs derived from natural products are attracting attention as a new alternative therapy. Filipendula glaberrima Nakai (FG) is a perennial plant in Korea. It is known to contain a variety of flavonoids with anti-inflammatory properties. In this study, the anti-inflammatory effects of the water extract of FG (FGW) were measured in vitro and in vivo. In vitro, FGW decreased the production of inflammatory mediators and its genes in LPS-stimulated macrophages. In addition, FGW downregulated the phosphorylation of the mitogen-activated protein kinase (MAPK) and nuclear factor-κB (NF-κB) signaling pathway-related proteins. In vivo, administration of FGW improved the clinical symptoms of inflammation and repaired the damaged epithelium in dextran sulfate sodium (DSS)-induced colitis mice. In conclusion, FGW has anti-inflammatory activity in vitro and in vivo and this activity was mediated through reducing the phosphorylation of the MAPK and NF-κB pathways.