The Implications of Pruritogens in the Pathogenesis of Atopic Dermatitis

Atopic dermatitis (AD) is a prototypic inflammatory disease that presents with intense itching. The pathophysiology of AD is multifactorial, involving environmental factors, genetic susceptibility, skin barrier function, and immune responses. A recent understanding of pruritus transmission provides...

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Bibliographic Details
Published in:International journal of molecular sciences 2021-07, Vol.22 (13), p.7227
Main Authors: Wong, Lai-San, Yen, Yu-Ta, Lee, Chih-Hung
Format: Article
Language:English
Subjects:
Atopic dermatitis
Cholestasis - complications
Cholestasis - physiopathology
Cholestasis - therapy
Cytokines
Cytokines - physiology
Dermatitis
Dermatitis, Atopic - etiology
Dermatitis, Atopic - physiopathology
Dermatitis, Atopic - therapy
Eczema
Exocrine glands
Gene expression
Histamine
Histamine - physiology
Humans
Immune response
Immune system
Inflammation
Inflammation Mediators - physiology
Inflammatory diseases
itch
Itching
Models, Biological
Nervous system
Neuroimmunomodulation - physiology
Pathogenesis
Pathophysiology
pruritogens
Pruritus
Pruritus - etiology
Pruritus - physiopathology
Pruritus - therapy
Psoriasis
Renal Insufficiency, Chronic - complications
Renal Insufficiency, Chronic - physiopathology
Renal Insufficiency, Chronic - therapy
Review
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Description
Summary:Atopic dermatitis (AD) is a prototypic inflammatory disease that presents with intense itching. The pathophysiology of AD is multifactorial, involving environmental factors, genetic susceptibility, skin barrier function, and immune responses. A recent understanding of pruritus transmission provides more information about the role of pruritogens in the pathogenesis of AD. There is evidence that pruritogens are not only responsible for eliciting pruritus, but also interact with immune cells and act as inflammatory mediators, which exacerbate the severity of AD. In this review, we discuss the interaction between pruritogens and inflammatory molecules and summarize the targeted therapies for AD.
ISSN:1422-0067
1661-6596
1422-0067
DOI:10.3390/ijms22137227