Transcriptomic analysis of Bursaphelenchus xylophilus treated by a potential phytonematicide, punicalagin

Punicalagin showed significant nematotoxic activity against pine wood nematode (PWN), , in the authors’ previous research. The authors performed high-throughput transcriptomic sequencing of punicalagin-treated nematodes to generate clues for its nematotoxic mechanism of action. The authors identifie...

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Bibliographic Details
Published in:Journal of nematology 2020-01, Vol.52 (1), p.1-14
Main Authors: Guo, Qun-Qun, Du, Gui-Cai, Zhang, Ting-Ting, Wang, Mei-Juan, Wang, Chao, Qi, Hong-Tao, Li, Rong-Gui
Format: Article
Language:English
Subjects:
Arts & Humanities
Differentially expressed genes
Nematotoxic mechanism
Pine wood nematode
Punicalagin
Transcriptomic analysis
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Summary:Punicalagin showed significant nematotoxic activity against pine wood nematode (PWN), , in the authors’ previous research. The authors performed high-throughput transcriptomic sequencing of punicalagin-treated nematodes to generate clues for its nematotoxic mechanism of action. The authors identified 2,575 differentially expressed genes, 1,428 of which were up-regulated and 1,147 down-regulated. Based on a comprehensive functional analysis, the authors speculate that PWN may respond to the stimulus of punicalagin through phagosome, endocytosis, peroxisome and MAPK signaling pathways. In addition, punicalagin could greatly affect PWN energy metabolism including oxidative phosphorylation. The genes encoding twitchin and a nematode cuticular collagen could be crucial regulation targets of punicalagin, which might contribute to its nematotoxic activity against PWN.
ISSN:0022-300X
2640-396X
2640-396X
DOI:10.21307/jofnem-2020-001