Animal Microbiomes as a Source of Novel Antibiotic-Producing Strains

Natural compounds continue to serve as the most fruitful source of new antimicrobials. Analysis of bacterial genomes have revealed that the biosynthetic potential of antibiotic producers by far exceeds the number of already discovered structures. However, due to the repeated discovery of known subst...

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Bibliographic Details
Published in:International journal of molecular sciences 2023-12, Vol.25 (1), p.537
Main Authors: Baranova, Margarita N, Pilipenko, Ekaterina A, Gabibov, Alexander G, Terekhov, Stanislav S, Smirnov, Ivan V
Format: Article
Language:English
Subjects:
Analysis
animal microbiota
Animals
Antibiotics
Antimicrobial agents
Bacteria
Competition
Environmental conditions
Fishes
Fungi
Genomics
Gram-positive bacteria
Invertebrates
Metabolism
Metabolites
Methicillin
Microbiota
Microbiota (Symbiotic organisms)
Microorganisms
Pathogens
probiotics
Review
secondary metabolites
Staphylococcus infections
Tuberculosis
wild microbiomes
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Summary:Natural compounds continue to serve as the most fruitful source of new antimicrobials. Analysis of bacterial genomes have revealed that the biosynthetic potential of antibiotic producers by far exceeds the number of already discovered structures. However, due to the repeated discovery of known substances, it has become necessary to change both approaches to the search for antibiotics and the sources of producer strains. The pressure of natural selection and the diversity of interactions in symbiotic communities make animal microbiomes promising sources of novel substances. Here, microorganisms associated with various animals were examined in terms of their antimicrobial agents. The application of alternative cultivation techniques, ultrahigh-throughput screening, and genomic analysis facilitated the investigation of compounds produced by unique representatives of the animal microbiota. We believe that new strategies of antipathogen defense will be discovered by precisely studying cell-cell and host-microbe interactions in microbiomes in the wild.
ISSN:1422-0067
1661-6596
1422-0067
DOI:10.3390/ijms25010537