Pseudo contrastive labeling for predicting IVF embryo developmental potential

• Published in: Scientific reports 2022-02, Vol.12 (1), p.2488-2488, Article 2488
• Main Authors: Erlich, I., Ben-Meir, A., Har-Vardi, I., Grifo, J., Wang, F., Mccaffrey, C., McCulloh, D., Or, Y., Wolf, L.
• Format: Article
• Language: English
• Subjects: 631/114; 639/166/985; Embryo Implantation; Embryo Transfer - methods; Embryonic Development; Embryos; Female; Fertilization in Vitro - methods; Genetic screening; Heterogeneity; Humanities and Social Sciences; Humans; In vitro fertilization; multidisciplinary; Science; Science (multidisciplinary); Training
• ISSN: 2045-2322; 2045-2322
• DOI: 10.1038/s41598-022-06336-y

In vitro fertilization is typically associated with high failure rates per transfer, leading to an acute need for the identification of embryos with high developmental potential. Current methods are tailored to specific times after fertilization, often require expert inspection, and have low predictive power. Automatic methods are challenged by ambiguous labels, clinical heterogeneity, and the inability to utilize multiple developmental points. In this work, we propose a novel method that trains a classifier conditioned on the time since fertilization. This classifier is then integrated over time and its output is used to assign soft labels to pairs of samples. The classifier obtained by training on these soft labels presents a significant improvement in accuracy, even as early as 30 h post-fertilization. By integrating the classification scores, the predictive power is further improved. Our results are superior to previously reported methods, including the commercial KIDScore-D3 system, and a group of eight senior professionals, in classifying multiple groups of favorable embryos into groups defined as less favorable based on implantation outcomes, expert decisions based on developmental trajectories, and/or genetic tests.